Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice

Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown. Here we show that TGF-β initiates and promotes HO in mice. We find that calcified cartilage and newly formed bone res...

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Detalles Bibliográficos
Autores principales: Wang, Xiao, Li, Fengfeng, Xie, Liang, Crane, Janet, Zhen, Gehua, Mishina, Yuji, Deng, Ruoxian, Gao, Bo, Chen, Hao, Liu, Shen, Yang, Ping, Gao, Manman, Tu, Manli, Wang, Yiguo, Wan, Mei, Fan, Cunyi, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803194/
https://www.ncbi.nlm.nih.gov/pubmed/29416028
http://dx.doi.org/10.1038/s41467-018-02988-5

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