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Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring. Metabolic...
Autores principales: | Wang, Yun-Qian, Wang, Hao-Lian, Xu, Jie, Tan, Juan, Fu, Lin-Na, Wang, Ji-Lin, Zou, Tian-Hui, Sun, Dan-Feng, Gao, Qin-Yan, Chen, Ying-Xuan, Fang, Jing-Yuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803207/ https://www.ncbi.nlm.nih.gov/pubmed/29416026 http://dx.doi.org/10.1038/s41467-018-02951-4 |
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