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Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

Post-translational modifications of the transcription elongation complex provide mechanisms to fine-tune gene expression, yet their specific impacts on RNA polymerase II regulation remain difficult to ascertain. Here, in Schizosaccharomyces pombe, we examine the role of Cdk9, and related Mcs6/Cdk7 a...

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Detalles Bibliográficos
Autores principales: Booth, Gregory T., Parua, Pabitra K., Sansó, Miriam, Fisher, Robert P., Lis, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803247/
https://www.ncbi.nlm.nih.gov/pubmed/29416031
http://dx.doi.org/10.1038/s41467-018-03006-4