A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, metabolic, and neurodegenerative diseases, cancers, a...

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Detalles Bibliográficos
Autores principales: Mahoney, Sarah J., Narayan, Sridhar, Molz, Lisa, Berstler, Lauren A., Kang, Seong A., Vlasuk, George P., Saiah, Eddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803267/
https://www.ncbi.nlm.nih.gov/pubmed/29416044
http://dx.doi.org/10.1038/s41467-018-03035-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803267/
https://www.ncbi.nlm.nih.gov/pubmed/29416044
http://dx.doi.org/10.1038/s41467-018-03035-z

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