Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood. Here, we show that miRNA biogenesis enzymes, Drosha and Dicer, control the recruitme...

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Detalles Bibliográficos
Autores principales: Lu, Wei-Ting, Hawley, Ben R., Skalka, George L., Baldock, Robert A., Smith, Ewan M., Bader, Aldo S., Malewicz, Michal, Watts, Felicity Z., Wilczynska, Ania, Bushell, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803274/
https://www.ncbi.nlm.nih.gov/pubmed/29416038
http://dx.doi.org/10.1038/s41467-018-02893-x

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