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LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population

Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237...

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Autores principales: Zhang, Zhuorong, Chang, Yitian, Jia, Wei, Zhang, Jiao, Zhang, Ruizhong, Zhu, Jinhong, Yang, Tianyou, Xia, Huimin, Zou, Yan, He, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803493/
https://www.ncbi.nlm.nih.gov/pubmed/29339420
http://dx.doi.org/10.1042/BSR20171667
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author Zhang, Zhuorong
Chang, Yitian
Jia, Wei
Zhang, Jiao
Zhang, Ruizhong
Zhu, Jinhong
Yang, Tianyou
Xia, Huimin
Zou, Yan
He, Jing
author_facet Zhang, Zhuorong
Chang, Yitian
Jia, Wei
Zhang, Jiao
Zhang, Ruizhong
Zhu, Jinhong
Yang, Tianyou
Xia, Huimin
Zou, Yan
He, Jing
author_sort Zhang, Zhuorong
collection PubMed
description Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C>T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06–3.06, P=0.029; TT/CT compared with CC: adjusted OR =1.31, 95% CI =1.02–1.67, P=0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06–1.58, P=0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06–2.14, P=0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12–2.30, P=0.011). In conclusion, we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings.
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spelling pubmed-58034932018-02-21 LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population Zhang, Zhuorong Chang, Yitian Jia, Wei Zhang, Jiao Zhang, Ruizhong Zhu, Jinhong Yang, Tianyou Xia, Huimin Zou, Yan He, Jing Biosci Rep Research Articles Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C>T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06–3.06, P=0.029; TT/CT compared with CC: adjusted OR =1.31, 95% CI =1.02–1.67, P=0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06–1.58, P=0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06–2.14, P=0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12–2.30, P=0.011). In conclusion, we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings. Portland Press Ltd. 2018-02-08 /pmc/articles/PMC5803493/ /pubmed/29339420 http://dx.doi.org/10.1042/BSR20171667 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Zhang, Zhuorong
Chang, Yitian
Jia, Wei
Zhang, Jiao
Zhang, Ruizhong
Zhu, Jinhong
Yang, Tianyou
Xia, Huimin
Zou, Yan
He, Jing
LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title_full LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title_fullStr LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title_full_unstemmed LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title_short LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
title_sort linc00673 rs11655237 c>t confers neuroblastoma susceptibility in chinese population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803493/
https://www.ncbi.nlm.nih.gov/pubmed/29339420
http://dx.doi.org/10.1042/BSR20171667
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