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LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population
Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803493/ https://www.ncbi.nlm.nih.gov/pubmed/29339420 http://dx.doi.org/10.1042/BSR20171667 |
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author | Zhang, Zhuorong Chang, Yitian Jia, Wei Zhang, Jiao Zhang, Ruizhong Zhu, Jinhong Yang, Tianyou Xia, Huimin Zou, Yan He, Jing |
author_facet | Zhang, Zhuorong Chang, Yitian Jia, Wei Zhang, Jiao Zhang, Ruizhong Zhu, Jinhong Yang, Tianyou Xia, Huimin Zou, Yan He, Jing |
author_sort | Zhang, Zhuorong |
collection | PubMed |
description | Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C>T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06–3.06, P=0.029; TT/CT compared with CC: adjusted OR =1.31, 95% CI =1.02–1.67, P=0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06–1.58, P=0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06–2.14, P=0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12–2.30, P=0.011). In conclusion, we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings. |
format | Online Article Text |
id | pubmed-5803493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58034932018-02-21 LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population Zhang, Zhuorong Chang, Yitian Jia, Wei Zhang, Jiao Zhang, Ruizhong Zhu, Jinhong Yang, Tianyou Xia, Huimin Zou, Yan He, Jing Biosci Rep Research Articles Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C>T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06–3.06, P=0.029; TT/CT compared with CC: adjusted OR =1.31, 95% CI =1.02–1.67, P=0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06–1.58, P=0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06–2.14, P=0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12–2.30, P=0.011). In conclusion, we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings. Portland Press Ltd. 2018-02-08 /pmc/articles/PMC5803493/ /pubmed/29339420 http://dx.doi.org/10.1042/BSR20171667 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Zhang, Zhuorong Chang, Yitian Jia, Wei Zhang, Jiao Zhang, Ruizhong Zhu, Jinhong Yang, Tianyou Xia, Huimin Zou, Yan He, Jing LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title | LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title_full | LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title_fullStr | LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title_full_unstemmed | LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title_short | LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population |
title_sort | linc00673 rs11655237 c>t confers neuroblastoma susceptibility in chinese population |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803493/ https://www.ncbi.nlm.nih.gov/pubmed/29339420 http://dx.doi.org/10.1042/BSR20171667 |
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