Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells

BACKGROUND: Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc lesional...

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Detalles Bibliográficos
Autores principales: Saigusa, Ryosuke, Asano, Yoshihide, Taniguchi, Takashi, Hirabayashi, Megumi, Nakamura, Kouki, Miura, Shunsuke, Yamashita, Takashi, Takahashi, Takehiro, Ichimura, Yohei, Toyama, Tetsuo, Yoshizaki, Ayumi, Trojanowska, Maria, Sato, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803841/
https://www.ncbi.nlm.nih.gov/pubmed/29415756
http://dx.doi.org/10.1186/s13075-018-1521-3

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