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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

BACKGROUND: Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities. METHODS: The effects of plocabulin on microtubule network...

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Detalles Bibliográficos
Autores principales:	Galmarini, Carlos M., Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803861/ https://www.ncbi.nlm.nih.gov/pubmed/29415678 http://dx.doi.org/10.1186/s12885-018-4086-2

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