Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

BACKGROUND: The anti-inflammatory effect of abatacept is most pronounced in patients with high-titer autoantibodies (including anticitrullinated protein antibodies [ACPA] and rheumatoid factor [RF]). Considering that autoantibodies trigger inflammatory cytokine production by monocytes and that abata...

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Detalles Bibliográficos
Autores principales: Bozec, Aline, Luo, Yubin, Engdahl, Cecilia, Figueiredo, Camille, Bang, Holger, Schett, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803926/
https://www.ncbi.nlm.nih.gov/pubmed/29415763
http://dx.doi.org/10.1186/s13075-018-1527-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803926/
https://www.ncbi.nlm.nih.gov/pubmed/29415763
http://dx.doi.org/10.1186/s13075-018-1527-x

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