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Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease
BACKGROUND: Enlarged tonsils and adenoids are the major etiology of obstructive sleep apnea (OSA) in children. Lymphatic hyperplasia is common to both OSA and celiac disease. We aimed to investigate the effect of a gluten-free diet on OSA symptoms in children with celiac disease. METHODS: Children w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803930/ https://www.ncbi.nlm.nih.gov/pubmed/29415685 http://dx.doi.org/10.1186/s12887-018-1039-5 |
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author | Yerushalmy-Feler, Anat Tauman, Riva Derowe, Ari Averbuch, Eran Ben-Tov, Amir Weintraub, Yael Weiner, Dror Amir, Achiya Moran-Lev, Hadar Cohen, Shlomi |
author_facet | Yerushalmy-Feler, Anat Tauman, Riva Derowe, Ari Averbuch, Eran Ben-Tov, Amir Weintraub, Yael Weiner, Dror Amir, Achiya Moran-Lev, Hadar Cohen, Shlomi |
author_sort | Yerushalmy-Feler, Anat |
collection | PubMed |
description | BACKGROUND: Enlarged tonsils and adenoids are the major etiology of obstructive sleep apnea (OSA) in children. Lymphatic hyperplasia is common to both OSA and celiac disease. We aimed to investigate the effect of a gluten-free diet on OSA symptoms in children with celiac disease. METHODS: Children with celiac disease aged 2–18 years were prospectively recruited before the initiation of a gluten-free diet. Children with negative celiac serology who underwent gastrointestinal endoscopies for other indications served as controls. All participants completed a validated OSA-related symptoms questionnaire and the pediatric sleep questionnaire (PSQ) at baseline and 6 months later. RESULTS: Thirty-four children with celiac disease (mean age 6.6 ± 3.5 years) and 24 controls (mean age 7.3 ± 4.6 years, P = 0.5) were recruited. There were no significant differences in gender, body mass index or season at recruitment between the two groups. The rate of positive PSQ scores was higher (more OSA-related symptoms) in the control group compared to the celiac group, both at recruitment and at the 6-month follow-up (33.3% vs. 11.8%, P = 0.046, and 16.7% vs. 0, P = 0.014, respectively). PSQ scores improved significantly in both groups at the 6-month follow-up (P < 0.001 for both). Improvement was significantly higher in the celiac group compared to controls (0.1 ± 0.09 vs.0.06 ± 0.06, respectively, P = 0.04). CONCLUSIONS: Children with celiac disease had fewer OSA-related symptoms than controls, but the degree of improvement following the initiation of a gluten-free diet was significantly higher. These findings suggest that a gluten-free diet may improve OSA-related symptoms in children with celiac disease. |
format | Online Article Text |
id | pubmed-5803930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58039302018-02-14 Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease Yerushalmy-Feler, Anat Tauman, Riva Derowe, Ari Averbuch, Eran Ben-Tov, Amir Weintraub, Yael Weiner, Dror Amir, Achiya Moran-Lev, Hadar Cohen, Shlomi BMC Pediatr Research Article BACKGROUND: Enlarged tonsils and adenoids are the major etiology of obstructive sleep apnea (OSA) in children. Lymphatic hyperplasia is common to both OSA and celiac disease. We aimed to investigate the effect of a gluten-free diet on OSA symptoms in children with celiac disease. METHODS: Children with celiac disease aged 2–18 years were prospectively recruited before the initiation of a gluten-free diet. Children with negative celiac serology who underwent gastrointestinal endoscopies for other indications served as controls. All participants completed a validated OSA-related symptoms questionnaire and the pediatric sleep questionnaire (PSQ) at baseline and 6 months later. RESULTS: Thirty-four children with celiac disease (mean age 6.6 ± 3.5 years) and 24 controls (mean age 7.3 ± 4.6 years, P = 0.5) were recruited. There were no significant differences in gender, body mass index or season at recruitment between the two groups. The rate of positive PSQ scores was higher (more OSA-related symptoms) in the control group compared to the celiac group, both at recruitment and at the 6-month follow-up (33.3% vs. 11.8%, P = 0.046, and 16.7% vs. 0, P = 0.014, respectively). PSQ scores improved significantly in both groups at the 6-month follow-up (P < 0.001 for both). Improvement was significantly higher in the celiac group compared to controls (0.1 ± 0.09 vs.0.06 ± 0.06, respectively, P = 0.04). CONCLUSIONS: Children with celiac disease had fewer OSA-related symptoms than controls, but the degree of improvement following the initiation of a gluten-free diet was significantly higher. These findings suggest that a gluten-free diet may improve OSA-related symptoms in children with celiac disease. BioMed Central 2018-02-07 /pmc/articles/PMC5803930/ /pubmed/29415685 http://dx.doi.org/10.1186/s12887-018-1039-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Yerushalmy-Feler, Anat Tauman, Riva Derowe, Ari Averbuch, Eran Ben-Tov, Amir Weintraub, Yael Weiner, Dror Amir, Achiya Moran-Lev, Hadar Cohen, Shlomi Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title | Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title_full | Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title_fullStr | Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title_full_unstemmed | Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title_short | Gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
title_sort | gluten-free diet may improve obstructive sleep apnea-related symptoms in children with celiac disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803930/ https://www.ncbi.nlm.nih.gov/pubmed/29415685 http://dx.doi.org/10.1186/s12887-018-1039-5 |
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