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APTM, a Thiophene Heterocyclic Compound, Inhibits Human Colon Cancer HCT116 Cell Proliferation Through p53-Dependent Induction of Apoptosis

To evaluate the in vitro anticancer activity and to investigate the mechanism of action of a thiophene heterocyclic compound, [3-Amino-5-[(2,6-dimethylphenyl)amino]-4-(phenylsulfonyl)-2-thienyl](4-fluorophenyl)methanone (APTM) against human colon cancer HCT116 cells. Sulforhodamine B assay and colon...

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Detalles Bibliográficos
Autores principales:	Liao, Xiaolin, Huang, Jiajun, Lin, Wanjun, Long, Ze, Xie, Ying, Ma, Wenzhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2018
Materias:	Original Research ArticlesOrganelles/Autophagy/Apoptosis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804089/ https://www.ncbi.nlm.nih.gov/pubmed/29215922 http://dx.doi.org/10.1089/dna.2017.3962

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