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Reward-Predictive Neural Activities in Striatal Striosome Compartments

The striatum has been shown to play a critical role in reward prediction. It is composed of two neurochemically and anatomically distinct compartments known as the striosomes and the matrix. The striosomes comprise only about 15% of the striatum by volume and are distributed mosaically therein. Acco...

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Detalles Bibliográficos
Autores principales: Yoshizawa, Tomohiko, Ito, Makoto, Doya, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804148/
https://www.ncbi.nlm.nih.gov/pubmed/29430520
http://dx.doi.org/10.1523/ENEURO.0367-17.2018
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author Yoshizawa, Tomohiko
Ito, Makoto
Doya, Kenji
author_facet Yoshizawa, Tomohiko
Ito, Makoto
Doya, Kenji
author_sort Yoshizawa, Tomohiko
collection PubMed
description The striatum has been shown to play a critical role in reward prediction. It is composed of two neurochemically and anatomically distinct compartments known as the striosomes and the matrix. The striosomes comprise only about 15% of the striatum by volume and are distributed mosaically therein. Accordingly, it has been difficult to identify striosomal neurons in electrophysiological recordings and it has been unclear whether striosomal neurons, which project to midbrain dopaminergic neurons, engage in reward prediction. In this study, we utilized a mouse line (Sepw1-NP67) selectively expressing Cre in striosomal neurons, combined with endoscopic in vivo calcium imaging to selectively record activities of striosomal neurons during an odor-conditioning task. As mice learned the task, striosomal neurons in the dorsomedial striatum (DMS) showed predictive activities to odor cues that were associated with water rewards or aversive air puffs. These activities were proportional to the expected reward or air-puff intensity. Intriguingly, repeated recordings of the same striosomal neurons over a period of weeks revealed that predictive activities were learning-stage specific. That is, these activities disappeared after continuous training. Furthermore, presentations of rewards or air puffs activated some striosomal neurons. These findings suggest that the striosomes participate in reward prediction with learning stage-specific neural ensembles, and that they also send reward and aversive signals to dopaminergic neurons.
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spelling pubmed-58041482018-02-09 Reward-Predictive Neural Activities in Striatal Striosome Compartments Yoshizawa, Tomohiko Ito, Makoto Doya, Kenji eNeuro New Research The striatum has been shown to play a critical role in reward prediction. It is composed of two neurochemically and anatomically distinct compartments known as the striosomes and the matrix. The striosomes comprise only about 15% of the striatum by volume and are distributed mosaically therein. Accordingly, it has been difficult to identify striosomal neurons in electrophysiological recordings and it has been unclear whether striosomal neurons, which project to midbrain dopaminergic neurons, engage in reward prediction. In this study, we utilized a mouse line (Sepw1-NP67) selectively expressing Cre in striosomal neurons, combined with endoscopic in vivo calcium imaging to selectively record activities of striosomal neurons during an odor-conditioning task. As mice learned the task, striosomal neurons in the dorsomedial striatum (DMS) showed predictive activities to odor cues that were associated with water rewards or aversive air puffs. These activities were proportional to the expected reward or air-puff intensity. Intriguingly, repeated recordings of the same striosomal neurons over a period of weeks revealed that predictive activities were learning-stage specific. That is, these activities disappeared after continuous training. Furthermore, presentations of rewards or air puffs activated some striosomal neurons. These findings suggest that the striosomes participate in reward prediction with learning stage-specific neural ensembles, and that they also send reward and aversive signals to dopaminergic neurons. Society for Neuroscience 2018-02-05 /pmc/articles/PMC5804148/ /pubmed/29430520 http://dx.doi.org/10.1523/ENEURO.0367-17.2018 Text en Copyright © 2018 Yoshizawa et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Yoshizawa, Tomohiko
Ito, Makoto
Doya, Kenji
Reward-Predictive Neural Activities in Striatal Striosome Compartments
title Reward-Predictive Neural Activities in Striatal Striosome Compartments
title_full Reward-Predictive Neural Activities in Striatal Striosome Compartments
title_fullStr Reward-Predictive Neural Activities in Striatal Striosome Compartments
title_full_unstemmed Reward-Predictive Neural Activities in Striatal Striosome Compartments
title_short Reward-Predictive Neural Activities in Striatal Striosome Compartments
title_sort reward-predictive neural activities in striatal striosome compartments
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804148/
https://www.ncbi.nlm.nih.gov/pubmed/29430520
http://dx.doi.org/10.1523/ENEURO.0367-17.2018
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