Cargando…

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

BACKGROUND: The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES: Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aguilera, Elena, Varela, Javier, Serna, Elva, Torres, Susana, Yaluff, Gloria, de Bilbao, Ninfa Vera, Cerecetto, Hugo, Alvarez, Guzmán, González, Mercedes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804306/ https://www.ncbi.nlm.nih.gov/pubmed/29412353 http://dx.doi.org/10.1590/0074-02760170267

Ejemplares similares

In Vivo Anti-Trypanosoma cruzi Activity of Hydro-Ethanolic Extract and Isolated Active Principles from Aristeguietia glutinosa and Mechanism of Action Studies
por: Varela, Javier, et al.
Publicado: (2014)

Perturbation of the Dimer Interface of Triosephosphate Isomerase and its Effect on Trypanosoma cruzi
por: Olivares-Illana, Vanesa, et al.
Publicado: (2007)

Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase
por: García-Torres, Itzhel, et al.
Publicado: (2023)

Sensibilidad in vitro a benznidazol, nifurtimox y posaconazol de cepas de Trypanosoma cruzi de Paraguay
por: Acosta, Nidia, et al.
Publicado: (2020)

Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease
por: Aguilera, Elena, et al.
Publicado: (2022)

Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity
por: Saramago, Luiz, et al.
Publicado: (2018)

Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease
por: Assíria Fontes Martins, Tassiane, et al.
Publicado: (2015)

Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
por: Calvet, Claudia Magalhães, et al.
Publicado: (2020)

Anti-Trypanosoma cruzi antibody profiling in patients with Chagas disease treated with benznidazole assessed by genome phage display
por: Rodriguez Carnero, Luis Antonio, et al.
Publicado: (2023)

Identification of fibrillogenic regions in human triosephosphate isomerase
por: Carcamo-Noriega, Edson N., et al.
Publicado: (2016)

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
por: Trochine, Andrea, et al.
Publicado: (2014)

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations
por: Lima, Davi Alvarenga, et al.
Publicado: (2023)

Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo
por: Batista, Denise da Gama Jaén, et al.
Publicado: (2011)

Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection
por: Li, Xiaomo, et al.
Publicado: (2021)

Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
por: Fonseca, Kátia da Silva, et al.
Publicado: (2021)

Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
por: de Oliveira-Silva, Jaquelline Carla Valamiel, et al.
Publicado: (2015)

Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies
por: Vázquez-Raygoza, Alejandra, et al.
Publicado: (2017)

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole
por: Téllez, Jair, et al.
Publicado: (2019)

Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert()
por: Campos, Mônica C.O., et al.
Publicado: (2014)

Miltefosine and Benznidazole Combination Improve Anti-Trypanosoma cruzi In Vitro and In Vivo Efficacy
por: Gulin, Julián Ernesto Nicolás, et al.
Publicado: (2022)

Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice
por: Gonzaga, Beatriz Matheus Souza, et al.
Publicado: (2022)

Structure of triosephosphate isomerase from Cryptosporidium parvum
por: Nguyen, Trang N., et al.
Publicado: (2011)

Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4(+)CD8(+) T cells in chronic Chagas disease patients
por: Pérez-Antón, Elena, et al.
Publicado: (2018)

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity
por: Ferraro, Florencia, et al.
Publicado: (2020)

Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi
por: dos Santos, Paula F, et al.
Publicado: (2012)

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
por: Zingales, Bianca, et al.
Publicado: (2015)

Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi
por: Puente, Vanesa, et al.
Publicado: (2018)

Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis
por: Grüning, Nana-Maria, et al.
Publicado: (2014)

Triosephosphate isomerase: the perfect enzyme, but how does it work?
por: Helliwell, John R.
Publicado: (2021)

Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells
por: Barbosa, Juliana Magalhães Chaves, et al.
Publicado: (2022)

Antiparasitic Activity of Hippeastrum Species and Synergistic Interaction between Montanine and Benznidazole against Trypanosoma cruzi
por: Piñeiro, Mauricio, et al.
Publicado: (2023)

Evaluation of the Chagas VirClia(®) and Chagas TESA VirClia(®) for the Diagnosis of Trypanosoma cruzi Infection
por: García-Bermejo, Isabel, et al.
Publicado: (2022)

Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp.
por: Álvarez, Guzmán, et al.
Publicado: (2017)

Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase
por: Zhai, Xiang, et al.
Publicado: (2015)

Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini
por: Son, Jonghyeon, et al.
Publicado: (2018)

Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target
por: Enríquez-Flores, Sergio, et al.
Publicado: (2020)

Meiotic sex in Chagas disease parasite Trypanosoma cruzi
por: Schwabl, Philipp, et al.
Publicado: (2019)

Peeking into the mysterious world of Trypanosoma cruzi and Chagas disease
por: Macedo, Andréa M, et al.
Publicado: (2022)

Trypanosoma cruzi and Chagas disease: diversity, progress and challenges
por: Miles, Michael A
Publicado: (2022)

A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids
por: Aguilera, Elena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1u1j3bngn8eqf4dnkvqkqjucrd