Cargando…

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has...

Descripción completa

Detalles Bibliográficos
Autores principales: Sangiovanni, Enrico, Brivio, Paola, Dell'Agli, Mario, Calabrese, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804326/
https://www.ncbi.nlm.nih.gov/pubmed/29464125
http://dx.doi.org/10.1155/2017/5965371
_version_ 1783298825727770624
author Sangiovanni, Enrico
Brivio, Paola
Dell'Agli, Mario
Calabrese, Francesca
author_facet Sangiovanni, Enrico
Brivio, Paola
Dell'Agli, Mario
Calabrese, Francesca
author_sort Sangiovanni, Enrico
collection PubMed
description The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.
format Online
Article
Text
id pubmed-5804326
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-58043262018-02-20 Botanicals as Modulators of Neuroplasticity: Focus on BDNF Sangiovanni, Enrico Brivio, Paola Dell'Agli, Mario Calabrese, Francesca Neural Plast Review Article The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment. Hindawi 2017 2017-12-31 /pmc/articles/PMC5804326/ /pubmed/29464125 http://dx.doi.org/10.1155/2017/5965371 Text en Copyright © 2017 Enrico Sangiovanni et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sangiovanni, Enrico
Brivio, Paola
Dell'Agli, Mario
Calabrese, Francesca
Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title_full Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title_fullStr Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title_full_unstemmed Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title_short Botanicals as Modulators of Neuroplasticity: Focus on BDNF
title_sort botanicals as modulators of neuroplasticity: focus on bdnf
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804326/
https://www.ncbi.nlm.nih.gov/pubmed/29464125
http://dx.doi.org/10.1155/2017/5965371
work_keys_str_mv AT sangiovannienrico botanicalsasmodulatorsofneuroplasticityfocusonbdnf
AT briviopaola botanicalsasmodulatorsofneuroplasticityfocusonbdnf
AT dellaglimario botanicalsasmodulatorsofneuroplasticityfocusonbdnf
AT calabresefrancesca botanicalsasmodulatorsofneuroplasticityfocusonbdnf