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Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes
Ability of environmental stressors to induce transgenerational diseases has been experimentally demonstrated in plants, worms, fish, and mammals, indicating that exposures affect not only human health but also fish and ecosystem health. Small aquarium fish have been reliable model to study genetic a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804509/ https://www.ncbi.nlm.nih.gov/pubmed/29492282 http://dx.doi.org/10.1093/eep/dvv010 |
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author | Bhandari, Ramji K. |
author_facet | Bhandari, Ramji K. |
author_sort | Bhandari, Ramji K. |
collection | PubMed |
description | Ability of environmental stressors to induce transgenerational diseases has been experimentally demonstrated in plants, worms, fish, and mammals, indicating that exposures affect not only human health but also fish and ecosystem health. Small aquarium fish have been reliable model to study genetic and epigenetic basis of development and disease. Additionally, fish can also provide better, economic opportunity to study transgenerational inheritance of adverse health and epigenetic mechanisms. Molecular mechanisms underlying germ cell development in fish are comparable to those in mammals and humans. This review will provide a short overview of long-term effects of environmental chemical contaminant exposure in various models, associated epigenetic mechanisms, and a perspective on fish as model to study environmentally induced transgenerational inheritance of altered phenotypes. |
format | Online Article Text |
id | pubmed-5804509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58045092018-02-28 Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes Bhandari, Ramji K. Environ Epigenet Review Article Ability of environmental stressors to induce transgenerational diseases has been experimentally demonstrated in plants, worms, fish, and mammals, indicating that exposures affect not only human health but also fish and ecosystem health. Small aquarium fish have been reliable model to study genetic and epigenetic basis of development and disease. Additionally, fish can also provide better, economic opportunity to study transgenerational inheritance of adverse health and epigenetic mechanisms. Molecular mechanisms underlying germ cell development in fish are comparable to those in mammals and humans. This review will provide a short overview of long-term effects of environmental chemical contaminant exposure in various models, associated epigenetic mechanisms, and a perspective on fish as model to study environmentally induced transgenerational inheritance of altered phenotypes. Oxford University Press 2016-01-30 /pmc/articles/PMC5804509/ /pubmed/29492282 http://dx.doi.org/10.1093/eep/dvv010 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Article Bhandari, Ramji K. Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title | Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title_full | Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title_fullStr | Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title_full_unstemmed | Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title_short | Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
title_sort | medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804509/ https://www.ncbi.nlm.nih.gov/pubmed/29492282 http://dx.doi.org/10.1093/eep/dvv010 |
work_keys_str_mv | AT bhandariramjik medakaasamodelforstudyingenvironmentallyinducedepigenetictransgenerationalinheritanceofphenotypes |