Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence

In utero exposure to environmental endocrine disruptors can cause transgenerational effects in the males of subsequent generations. DNA methylation (5 mC) was suggested, but being challenged as the molecular carrier of such epigenetic information. In a recent study, Schuster et al. show a changed sm...

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Detalles Bibliográficos
Autores principales: Shi, Junchao, Zhang, Yunfang, Chen, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804526/
https://www.ncbi.nlm.nih.gov/pubmed/29492292
http://dx.doi.org/10.1093/eep/dvw014
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author Shi, Junchao
Zhang, Yunfang
Chen, Qi
author_facet Shi, Junchao
Zhang, Yunfang
Chen, Qi
author_sort Shi, Junchao
collection PubMed
description In utero exposure to environmental endocrine disruptors can cause transgenerational effects in the males of subsequent generations. DNA methylation (5 mC) was suggested, but being challenged as the molecular carrier of such epigenetic information. In a recent study, Schuster et al. show a changed small RNA profile changed in the sperm of F3 generation after F0 in utero vinclozolin exposure, suggesting additional transgenerational epigenetic carriers for endocrine disruptor effects, other than DNA methylation.
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spelling pubmed-58045262018-02-28 Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence Shi, Junchao Zhang, Yunfang Chen, Qi Environ Epigenet Research Highlight In utero exposure to environmental endocrine disruptors can cause transgenerational effects in the males of subsequent generations. DNA methylation (5 mC) was suggested, but being challenged as the molecular carrier of such epigenetic information. In a recent study, Schuster et al. show a changed small RNA profile changed in the sperm of F3 generation after F0 in utero vinclozolin exposure, suggesting additional transgenerational epigenetic carriers for endocrine disruptor effects, other than DNA methylation. Oxford University Press 2016-08-03 /pmc/articles/PMC5804526/ /pubmed/29492292 http://dx.doi.org/10.1093/eep/dvw014 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Highlight
Shi, Junchao
Zhang, Yunfang
Chen, Qi
Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title_full Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title_fullStr Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title_full_unstemmed Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title_short Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
title_sort molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804526/
https://www.ncbi.nlm.nih.gov/pubmed/29492292
http://dx.doi.org/10.1093/eep/dvw014
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