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Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta

OBJECTIVE: To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. METHODS: Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin–eosin st...

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Autores principales: Amudong, Aierken, Muheremu, Aikeremujiang, Abudourexiti, Tuerhongjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805210/
https://www.ncbi.nlm.nih.gov/pubmed/28635357
http://dx.doi.org/10.1177/0300060517711308
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author Amudong, Aierken
Muheremu, Aikeremujiang
Abudourexiti, Tuerhongjiang
author_facet Amudong, Aierken
Muheremu, Aikeremujiang
Abudourexiti, Tuerhongjiang
author_sort Amudong, Aierken
collection PubMed
description OBJECTIVE: To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. METHODS: Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin–eosin staining and transforming growth factor beta (TGF-β) immunohistochemical testing were applied to compare these two groups. RESULTS: Derangement of fibrous alignment, fibrocartilage changes, and infiltration of inflammatory cells were observed in the patients with hypertrophy of the ligamentum flavum, while fibrous alignment was normal and few inflammatory cells were observed in patients without hypertrophy. Immunohistochemical studies showed positive expression of TGF-β in patients with hypertrophy, while expression was negative in patients without hypertrophy. The integrated optical density was 2.6556708 in the hypertrophy group and 23104671 in the normal controls. CONCLUSIONS: Expression of TGF-β was closely related to hypertrophy of the ligamentum flavum. Appropriate application of the TGF-β expression level can be used to predict progression of hypertrophy of the ligamentum flavum.
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spelling pubmed-58052102018-02-14 Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta Amudong, Aierken Muheremu, Aikeremujiang Abudourexiti, Tuerhongjiang J Int Med Res Research Report OBJECTIVE: To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. METHODS: Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin–eosin staining and transforming growth factor beta (TGF-β) immunohistochemical testing were applied to compare these two groups. RESULTS: Derangement of fibrous alignment, fibrocartilage changes, and infiltration of inflammatory cells were observed in the patients with hypertrophy of the ligamentum flavum, while fibrous alignment was normal and few inflammatory cells were observed in patients without hypertrophy. Immunohistochemical studies showed positive expression of TGF-β in patients with hypertrophy, while expression was negative in patients without hypertrophy. The integrated optical density was 2.6556708 in the hypertrophy group and 23104671 in the normal controls. CONCLUSIONS: Expression of TGF-β was closely related to hypertrophy of the ligamentum flavum. Appropriate application of the TGF-β expression level can be used to predict progression of hypertrophy of the ligamentum flavum. SAGE Publications 2017-06-21 2017-12 /pmc/articles/PMC5805210/ /pubmed/28635357 http://dx.doi.org/10.1177/0300060517711308 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Report
Amudong, Aierken
Muheremu, Aikeremujiang
Abudourexiti, Tuerhongjiang
Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title_full Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title_fullStr Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title_full_unstemmed Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title_short Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
title_sort hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805210/
https://www.ncbi.nlm.nih.gov/pubmed/28635357
http://dx.doi.org/10.1177/0300060517711308
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