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Country of infection among HIV-infected patients born abroad living in French Guiana
BACKGROUND: Over 75% of patients in the HIV cohort in French Guiana are of foreign origin. Our objective was to estimate what proportion of the migrant population of HIV-infected patients in Cayenne had been infected in French Guiana. METHODS: We included patients of known foreign origin who were fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805311/ https://www.ncbi.nlm.nih.gov/pubmed/29420591 http://dx.doi.org/10.1371/journal.pone.0192564 |
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author | Nacher, Mathieu Adriouch, Leila Van Melle, Astrid Parriault, Marie-Claire Adenis, Antoine Couppié, Pierre |
author_facet | Nacher, Mathieu Adriouch, Leila Van Melle, Astrid Parriault, Marie-Claire Adenis, Antoine Couppié, Pierre |
author_sort | Nacher, Mathieu |
collection | PubMed |
description | BACKGROUND: Over 75% of patients in the HIV cohort in French Guiana are of foreign origin. Our objective was to estimate what proportion of the migrant population of HIV-infected patients in Cayenne had been infected in French Guiana. METHODS: We included patients of known foreign origin who were followed in Cayenne, for whom the year of arrival in French Guiana was known and the initial CD4 count at the time of diagnosis was available. The time between seroconversion and time at diagnosis was estimated using the formula [square root (CD4 at seroconversion)-square root(CD4 at HIV diagnosis)] / slope of CD4 decline.CD4 counts at the time of infection and the slope were computed in an age and ethnicity-dependent variable. RESULTS: The median estimated time between infection and diagnosis was 4.5 years (IQR = 0.2–9.2). Overall, using a median estimate of CD4 count at the time of infection, it was estimated that 53.2% (95% CI = 48.3–58%) of HIV infected foreign patients had acquired HIV after having arrived in French Guiana. Patients having arrived in French Guiana before and during the 1990s and those receiving their HIV diagnosis before 2010 were more likely to have been infected in French Guiana. CONCLUSIONS: Contrary to widespread belief suggesting that most migrants are already HIV-infected when they arrive in French Guiana, a large proportion of foreign HIV patients seem acquire the virus in French Guiana.There is still much to do in terms of primary prevention and testing among migrants. |
format | Online Article Text |
id | pubmed-5805311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58053112018-02-23 Country of infection among HIV-infected patients born abroad living in French Guiana Nacher, Mathieu Adriouch, Leila Van Melle, Astrid Parriault, Marie-Claire Adenis, Antoine Couppié, Pierre PLoS One Research Article BACKGROUND: Over 75% of patients in the HIV cohort in French Guiana are of foreign origin. Our objective was to estimate what proportion of the migrant population of HIV-infected patients in Cayenne had been infected in French Guiana. METHODS: We included patients of known foreign origin who were followed in Cayenne, for whom the year of arrival in French Guiana was known and the initial CD4 count at the time of diagnosis was available. The time between seroconversion and time at diagnosis was estimated using the formula [square root (CD4 at seroconversion)-square root(CD4 at HIV diagnosis)] / slope of CD4 decline.CD4 counts at the time of infection and the slope were computed in an age and ethnicity-dependent variable. RESULTS: The median estimated time between infection and diagnosis was 4.5 years (IQR = 0.2–9.2). Overall, using a median estimate of CD4 count at the time of infection, it was estimated that 53.2% (95% CI = 48.3–58%) of HIV infected foreign patients had acquired HIV after having arrived in French Guiana. Patients having arrived in French Guiana before and during the 1990s and those receiving their HIV diagnosis before 2010 were more likely to have been infected in French Guiana. CONCLUSIONS: Contrary to widespread belief suggesting that most migrants are already HIV-infected when they arrive in French Guiana, a large proportion of foreign HIV patients seem acquire the virus in French Guiana.There is still much to do in terms of primary prevention and testing among migrants. Public Library of Science 2018-02-08 /pmc/articles/PMC5805311/ /pubmed/29420591 http://dx.doi.org/10.1371/journal.pone.0192564 Text en © 2018 Nacher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nacher, Mathieu Adriouch, Leila Van Melle, Astrid Parriault, Marie-Claire Adenis, Antoine Couppié, Pierre Country of infection among HIV-infected patients born abroad living in French Guiana |
title | Country of infection among HIV-infected patients born abroad living in French Guiana |
title_full | Country of infection among HIV-infected patients born abroad living in French Guiana |
title_fullStr | Country of infection among HIV-infected patients born abroad living in French Guiana |
title_full_unstemmed | Country of infection among HIV-infected patients born abroad living in French Guiana |
title_short | Country of infection among HIV-infected patients born abroad living in French Guiana |
title_sort | country of infection among hiv-infected patients born abroad living in french guiana |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805311/ https://www.ncbi.nlm.nih.gov/pubmed/29420591 http://dx.doi.org/10.1371/journal.pone.0192564 |
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