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Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface

The ecto-5’-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology. Indeed, the anticancer immune response involves extracellular ATP to block cell proliferation through T-cell activat...

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Detalles Bibliográficos
Autores principales:	Rahimova, Rahila, Fontanel, Simon, Lionne, Corinne, Jordheim, Lars Peter, Peyrottes, Suzanne, Chaloin, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805337/ https://www.ncbi.nlm.nih.gov/pubmed/29377887 http://dx.doi.org/10.1371/journal.pcbi.1005943

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