Cargando…
Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes
Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy metabolism, different viruses have been shown to rely on alternative mechanisms of metabolic activation. Whether related viruses exploit conserved...
Autores principales: | Mazzon, Michela, Castro, Cecilia, Thaa, Bastian, Liu, Lifeng, Mutso, Margit, Liu, Xiang, Mahalingam, Suresh, Griffin, Julian L., Marsh, Mark, McInerney, Gerald M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805360/ https://www.ncbi.nlm.nih.gov/pubmed/29377936 http://dx.doi.org/10.1371/journal.ppat.1006835 |
Ejemplares similares
-
Activation of the PI3K-AKT Pathway by Old World Alphaviruses
por: Van Huizen, Eline, et al.
Publicado: (2020) -
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
por: Schulte, Tim, et al.
Publicado: (2016) -
Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus
por: Mutso, Margit, et al.
Publicado: (2018) -
The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last
por: Götte, Benjamin, et al.
Publicado: (2018) -
Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery
por: Götte, Benjamin, et al.
Publicado: (2019)