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Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding genes of the viral host without changing the amin...

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Detalles Bibliográficos
Autores principales:	Eschke, Kathrin, Trimpert, Jakob, Osterrieder, Nikolaus, Kunec, Dusan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805365/ https://www.ncbi.nlm.nih.gov/pubmed/29377958 http://dx.doi.org/10.1371/journal.ppat.1006857

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