Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies

Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. Ho...

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Detalles Bibliográficos
Autores principales: O’Brien, Lori L., Guo, Qiuyu, Bahrami-Samani, Emad, Park, Joo-Seop, Hasso, Sean M., Lee, Young-Jin, Fang, Alan, Kim, Albert D., Guo, Jinjin, Hong, Trudy M., Peterson, Kevin A., Lozanoff, Scott, Raviram, Ramya, Ren, Bing, Fogelgren, Ben, Smith, Andrew D., Valouev, Anton, McMahon, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805373/
https://www.ncbi.nlm.nih.gov/pubmed/29377931
http://dx.doi.org/10.1371/journal.pgen.1007181

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