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The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials
BACKGROUND: Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805418/ https://www.ncbi.nlm.nih.gov/pubmed/29384846 http://dx.doi.org/10.1097/MD.0000000000009679 |
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author | Wang, Lang Guo, Mao-Juan Gao, Qing Yang, Jin-Feng Yang, Lin Pang, Xiao-Li Jiang, Xi-Juan |
author_facet | Wang, Lang Guo, Mao-Juan Gao, Qing Yang, Jin-Feng Yang, Lin Pang, Xiao-Li Jiang, Xi-Juan |
author_sort | Wang, Lang |
collection | PubMed |
description | BACKGROUND: Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies. METHODS: Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis. RESULTS: Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = −13.27, 95% CI (−16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = −8.30, 95% CI (−10.44, −6.15), P < .05]; VSL#3 [MD = −11.04, 95% CI (−19.61, −2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = −1.56, 95% CI (−6.97, −3.86), P < .05] or t > 6 weeks: [MD = −22.18, 95% CI (−28.73, −15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects. CONCLUSION: Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect. |
format | Online Article Text |
id | pubmed-5805418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-58054182018-02-20 The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials Wang, Lang Guo, Mao-Juan Gao, Qing Yang, Jin-Feng Yang, Lin Pang, Xiao-Li Jiang, Xi-Juan Medicine (Baltimore) 3400 BACKGROUND: Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies. METHODS: Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis. RESULTS: Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = −13.27, 95% CI (−16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = −8.30, 95% CI (−10.44, −6.15), P < .05]; VSL#3 [MD = −11.04, 95% CI (−19.61, −2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = −1.56, 95% CI (−6.97, −3.86), P < .05] or t > 6 weeks: [MD = −22.18, 95% CI (−28.73, −15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects. CONCLUSION: Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect. Wolters Kluwer Health 2018-02-02 /pmc/articles/PMC5805418/ /pubmed/29384846 http://dx.doi.org/10.1097/MD.0000000000009679 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 3400 Wang, Lang Guo, Mao-Juan Gao, Qing Yang, Jin-Feng Yang, Lin Pang, Xiao-Li Jiang, Xi-Juan The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title | The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title_full | The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title_fullStr | The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title_full_unstemmed | The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title_short | The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials |
title_sort | effects of probiotics on total cholesterol: a meta-analysis of randomized controlled trials |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805418/ https://www.ncbi.nlm.nih.gov/pubmed/29384846 http://dx.doi.org/10.1097/MD.0000000000009679 |
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