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Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study
Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805432/ https://www.ncbi.nlm.nih.gov/pubmed/29384860 http://dx.doi.org/10.1097/MD.0000000000009750 |
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author | Kurcova, Sandra Bardon, Jan Vastik, Miroslav Vecerkova, Marketa Frolova, Monika Hvizdosova, Lenka Nevrly, Martin Mensikova, Katerina Otruba, Pavel Krahulik, David Kurca, Egon Sivak, Stefan Zapletalova, Jana Kanovsky, Petr |
author_facet | Kurcova, Sandra Bardon, Jan Vastik, Miroslav Vecerkova, Marketa Frolova, Monika Hvizdosova, Lenka Nevrly, Martin Mensikova, Katerina Otruba, Pavel Krahulik, David Kurca, Egon Sivak, Stefan Zapletalova, Jana Kanovsky, Petr |
author_sort | Kurcova, Sandra |
collection | PubMed |
description | Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up. This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores (P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores (P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 (P < .001); at Month 4, it remained significantly lower than before stimulation (P = .036). There was no significant difference in The Parkinson's Disease Sleep Scaleat Month 1 and significant improvement at Month 4 (P = .026). There were no significant changes in The Female Sexual Function Index or International Index of Erectile Function. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III scores show significant improvements at Month 1 (P < .001) and at Month 4 (P < .001). STN-DBS in patients with advanced PD clearly improves not only motor symptoms, but also several domains of nonmotor functions, namely sleep, autonomic functions and quality of life quickly following the start of stimulation. |
format | Online Article Text |
id | pubmed-5805432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-58054322018-02-20 Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study Kurcova, Sandra Bardon, Jan Vastik, Miroslav Vecerkova, Marketa Frolova, Monika Hvizdosova, Lenka Nevrly, Martin Mensikova, Katerina Otruba, Pavel Krahulik, David Kurca, Egon Sivak, Stefan Zapletalova, Jana Kanovsky, Petr Medicine (Baltimore) 5300 Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains. Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up. This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores (P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores (P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 (P < .001); at Month 4, it remained significantly lower than before stimulation (P = .036). There was no significant difference in The Parkinson's Disease Sleep Scaleat Month 1 and significant improvement at Month 4 (P = .026). There were no significant changes in The Female Sexual Function Index or International Index of Erectile Function. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III scores show significant improvements at Month 1 (P < .001) and at Month 4 (P < .001). STN-DBS in patients with advanced PD clearly improves not only motor symptoms, but also several domains of nonmotor functions, namely sleep, autonomic functions and quality of life quickly following the start of stimulation. Wolters Kluwer Health 2018-02-02 /pmc/articles/PMC5805432/ /pubmed/29384860 http://dx.doi.org/10.1097/MD.0000000000009750 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5300 Kurcova, Sandra Bardon, Jan Vastik, Miroslav Vecerkova, Marketa Frolova, Monika Hvizdosova, Lenka Nevrly, Martin Mensikova, Katerina Otruba, Pavel Krahulik, David Kurca, Egon Sivak, Stefan Zapletalova, Jana Kanovsky, Petr Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title | Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title_full | Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title_fullStr | Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title_full_unstemmed | Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title_short | Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study |
title_sort | bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in parkinson's disease: an open prospective single institution study |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805432/ https://www.ncbi.nlm.nih.gov/pubmed/29384860 http://dx.doi.org/10.1097/MD.0000000000009750 |
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