Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and end...

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Detalles Bibliográficos
Autores principales: Hsu, Sanford P.C., Kuo, John S., Chiang, Hsin-Chien, Wang, Hsin-Ell, Wang, Yu-Shan, Huang, Cheng-Chung, Huang, Yi-Chun, Chi, Mau-Shin, Mehta, Minesh P., Chi, Kwan-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805523/
https://www.ncbi.nlm.nih.gov/pubmed/29467937
http://dx.doi.org/10.18632/oncotarget.23855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805523/
https://www.ncbi.nlm.nih.gov/pubmed/29467937
http://dx.doi.org/10.18632/oncotarget.23855

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