Cargando…

Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and end...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsu, Sanford P.C., Kuo, John S., Chiang, Hsin-Chien, Wang, Hsin-Ell, Wang, Yu-Shan, Huang, Cheng-Chung, Huang, Yi-Chun, Chi, Mau-Shin, Mehta, Minesh P., Chi, Kwan-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805523/ https://www.ncbi.nlm.nih.gov/pubmed/29467937 http://dx.doi.org/10.18632/oncotarget.23855

Ejemplares similares

Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy
por: Chi, Kwan-Hwa, et al.
Publicado: (2016)

Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis
por: Baumer, Yvonne, et al.
Publicado: (2020)

Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors
por: Hsu, Sanford P. C., et al.
Publicado: (2020)

In vitro comparison of conventional hyperthermia and modulated electro-hyperthermia
por: Yang, Kai-Lin, et al.
Publicado: (2016)

Morusin Enhances Temozolomide Efficiency in GBM by Inducing Cytoplasmic Vacuolization and Endoplasmic Reticulum Stress
por: Zhao, Rongchuan, et al.
Publicado: (2022)

TMEM2 induces epithelial-mesenchymal transition and promotes resistance to temozolomide in GBM cells
por: Gao, Lun, et al.
Publicado: (2023)

In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi
por: Son, Dongwook, et al.
Publicado: (2014)

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide
por: Parik, Sweta, et al.
Publicado: (2022)

Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling
por: Alafate, Wahafu, et al.
Publicado: (2020)

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death
por: Schmukler, Eran, et al.
Publicado: (2013)

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export
por: Li, Jian, et al.
Publicado: (2016)

Temozolomide and chloroquine co-loaded mesoporous silica nanoparticles are effective against glioma
por: Zhang, Peng, et al.
Publicado: (2023)

Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling
Publicado: (1980)

OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth()()
por: Towner, Rheal A., et al.
Publicado: (2018)

Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial-Dependent Apoptosis in GBM Cells, Which Is Regulated by Autophagy
por: Hajiahmadi, Sima, et al.
Publicado: (2023)

Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial
por: Compter, Inge, et al.
Publicado: (2020)

Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor
por: Hannen, Ricarda, et al.
Publicado: (2019)

Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines
por: Lombardi, Francesca, et al.
Publicado: (2022)

Retraction Note: BET inhibitor I-BET151 sensitizes GBM cells to temozolomide via PUMA induction
por: Yao, Zhicheng, et al.
Publicado: (2022)

Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells
por: Cardoso, M. Helena, et al.
Publicado: (2023)

Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models
por: Valtorta, Silvia, et al.
Publicado: (2017)

The efficacy of temozolomide combined with levetiracetam for glioblastoma (GBM) after surgery: a study protocol for a double-blinded and randomized controlled trial
por: Sun, Maoyuan, et al.
Publicado: (2022)

Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM
por: Biswas, Nidhan K., et al.
Publicado: (2015)

Intracranial In Situ Thermosensitive Hydrogel Delivery of Temozolomide Accomplished by PLGA–PEG–PLGA Triblock Copolymer Blending for GBM Treatment
por: Gu, Weinan, et al.
Publicado: (2022)

Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics
por: Al‐Bari, Md. Abdul Alim
Publicado: (2020)

Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress
por: Gregório, PauloC., et al.
Publicado: (2021)

A Multi-Site Phase I Trial of Veliparib with Standard Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme (GBM)
por: Kleinberg, Lawrence, et al.
Publicado: (2023)

Chloroquine and Hydroxychloroquine: Efficacy in the Treatment of the COVID-19
por: Ho, Tzu-Chuan, et al.
Publicado: (2021)

The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects
por: Shen, Hong-Yuan, et al.
Publicado: (2022)

Involvement of Intracellular Cholesterol in Temozolomide-Induced Glioblastoma Cell Death
por: YAMAMOTO, Yutaro, et al.
Publicado: (2018)

BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide
por: CHEN, CHIEN-MIN, et al.
Publicado: (2015)

Use of BODIPY‐Cholesterol (TF‐Chol) for Visualizing Lysosomal Cholesterol Accumulation
por: Hölttä‐Vuori, Maarit, et al.
Publicado: (2016)

Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content
por: Appelqvist, Hanna, et al.
Publicado: (2012)

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration
por: Chen, Patrick M, et al.
Publicado: (2011)

SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma
por: Wojton, Jeffrey, et al.
Publicado: (2014)

The synergic antitumor effects of paclitaxel and temozolomide co-loaded in mPEG-PLGA nanoparticles on glioblastoma cells
por: Xu, Yuanyuan, et al.
Publicado: (2016)

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro
por: Matteoni, Silvia, et al.
Publicado: (2021)

Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide
por: Wang, Yan, et al.
Publicado: (2021)

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma
por: Cui, Xiaoteng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fbn4mrol4d6g285rdn1g48deku