ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

Advances in oral SERDs development so far have been confined to nonsteroidal molecules such as those containing a cinnamic acid moiety, which are in earlystage clinical evaluation. ZB716 was previously reported as an orally bioavailable SERD structurally analogous to fulvestrant. In this study, we e...

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Detalles Bibliográficos
Autores principales: Guo, Shanchun, Zhang, Changde, Bratton, Melyssa, Mottamal, Madhusoodanan, Liu, Jiawang, Ma, Peng, Zheng, Shilong, Zhong, Qiu, Yang, Lin, Wiese, Thomas E., Wu, Yong, Ellis, Matthew J., Matossian, Margarite, Burow, Matthew E., Miele, Lucio, Houtman, René, Wang, Guangdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805526/
https://www.ncbi.nlm.nih.gov/pubmed/29467940
http://dx.doi.org/10.18632/oncotarget.24023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805526/
https://www.ncbi.nlm.nih.gov/pubmed/29467940
http://dx.doi.org/10.18632/oncotarget.24023

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