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Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic C...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680/ https://www.ncbi.nlm.nih.gov/pubmed/29422604 http://dx.doi.org/10.1038/s41467-018-02942-5 |
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| author | Klein, Alison P. Wolpin, Brian M. Risch, Harvey A. Stolzenberg-Solomon, Rachael Z. Mocci, Evelina Zhang, Mingfeng Canzian, Federico Childs, Erica J. Hoskins, Jason W. Jermusyk, Ashley Zhong, Jun Chen, Fei Albanes, Demetrius Andreotti, Gabriella Arslan, Alan A. Babic, Ana Bamlet, William R. Beane-Freeman, Laura Berndt, Sonja I. Blackford, Amanda Borges, Michael Borgida, Ayelet Bracci, Paige M. Brais, Lauren Brennan, Paul Brenner, Hermann Bueno-de-Mesquita, Bas Buring, Julie Campa, Daniele Capurso, Gabriele Cavestro, Giulia Martina Chaffee, Kari G. Chung, Charles C. Cleary, Sean Cotterchio, Michelle Dijk, Frederike Duell, Eric J. Foretova, Lenka Fuchs, Charles Funel, Niccola Gallinger, Steven M. Gaziano, J. Michael Gazouli, Maria Giles, Graham G. Giovannucci, Edward Goggins, Michael Goodman, Gary E. Goodman, Phyllis J. Hackert, Thilo Haiman, Christopher Hartge, Patricia Hasan, Manal Hegyi, Peter Helzlsouer, Kathy J. Herman, Joseph Holcatova, Ivana Holly, Elizabeth A. Hoover, Robert Hung, Rayjean J. Jacobs, Eric J. Jamroziak, Krzysztof Janout, Vladimir Kaaks, Rudolf Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Kooperberg, Charles Kulke, Matthew H. Kupcinskas, Juozas Kurtz, Robert J. Laheru, Daniel Landi, Stefano Lawlor, Rita T. Lee, I.-Min LeMarchand, Loic Lu, Lingeng Malats, Núria Mambrini, Andrea Mannisto, Satu Milne, Roger L. Mohelníková-Duchoňová, Beatrice Neale, Rachel E. Neoptolemos, John P. Oberg, Ann L. Olson, Sara H. Orlow, Irene Pasquali, Claudio Patel, Alpa V. Peters, Ulrike Pezzilli, Raffaele Porta, Miquel Real, Francisco X. Rothman, Nathaniel Scelo, Ghislaine Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Silverman, Debra Smith, Jill P. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Tavano, Francesca Thornquist, Mark D. Tobias, Geoffrey S. Van Den Eeden, Stephen K. Vashist, Yogesh Visvanathan, Kala Vodicka, Pavel Wactawski-Wende, Jean Wang, Zhaoming Wentzensen, Nicolas White, Emily Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Zheng, Wei Kraft, Peter Li, Donghui Chanock, Stephen Obazee, Ofure Petersen, Gloria M. Amundadottir, Laufey T. |
| author_facet | Klein, Alison P. Wolpin, Brian M. Risch, Harvey A. Stolzenberg-Solomon, Rachael Z. Mocci, Evelina Zhang, Mingfeng Canzian, Federico Childs, Erica J. Hoskins, Jason W. Jermusyk, Ashley Zhong, Jun Chen, Fei Albanes, Demetrius Andreotti, Gabriella Arslan, Alan A. Babic, Ana Bamlet, William R. Beane-Freeman, Laura Berndt, Sonja I. Blackford, Amanda Borges, Michael Borgida, Ayelet Bracci, Paige M. Brais, Lauren Brennan, Paul Brenner, Hermann Bueno-de-Mesquita, Bas Buring, Julie Campa, Daniele Capurso, Gabriele Cavestro, Giulia Martina Chaffee, Kari G. Chung, Charles C. Cleary, Sean Cotterchio, Michelle Dijk, Frederike Duell, Eric J. Foretova, Lenka Fuchs, Charles Funel, Niccola Gallinger, Steven M. Gaziano, J. Michael Gazouli, Maria Giles, Graham G. Giovannucci, Edward Goggins, Michael Goodman, Gary E. Goodman, Phyllis J. Hackert, Thilo Haiman, Christopher Hartge, Patricia Hasan, Manal Hegyi, Peter Helzlsouer, Kathy J. Herman, Joseph Holcatova, Ivana Holly, Elizabeth A. Hoover, Robert Hung, Rayjean J. Jacobs, Eric J. Jamroziak, Krzysztof Janout, Vladimir Kaaks, Rudolf Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Kooperberg, Charles Kulke, Matthew H. Kupcinskas, Juozas Kurtz, Robert J. Laheru, Daniel Landi, Stefano Lawlor, Rita T. Lee, I.-Min LeMarchand, Loic Lu, Lingeng Malats, Núria Mambrini, Andrea Mannisto, Satu Milne, Roger L. Mohelníková-Duchoňová, Beatrice Neale, Rachel E. Neoptolemos, John P. Oberg, Ann L. Olson, Sara H. Orlow, Irene Pasquali, Claudio Patel, Alpa V. Peters, Ulrike Pezzilli, Raffaele Porta, Miquel Real, Francisco X. Rothman, Nathaniel Scelo, Ghislaine Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Silverman, Debra Smith, Jill P. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Tavano, Francesca Thornquist, Mark D. Tobias, Geoffrey S. Van Den Eeden, Stephen K. Vashist, Yogesh Visvanathan, Kala Vodicka, Pavel Wactawski-Wende, Jean Wang, Zhaoming Wentzensen, Nicolas White, Emily Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Zheng, Wei Kraft, Peter Li, Donghui Chanock, Stephen Obazee, Ofure Petersen, Gloria M. Amundadottir, Laufey T. |
| author_sort | Klein, Alison P. |
| collection | PubMed |
| description | In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10(−8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10(−14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10(−10)), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10(−8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10(−8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. |
| format | Online Article Text |
| id | pubmed-5805680 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58056802018-02-12 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer Klein, Alison P. Wolpin, Brian M. Risch, Harvey A. Stolzenberg-Solomon, Rachael Z. Mocci, Evelina Zhang, Mingfeng Canzian, Federico Childs, Erica J. Hoskins, Jason W. Jermusyk, Ashley Zhong, Jun Chen, Fei Albanes, Demetrius Andreotti, Gabriella Arslan, Alan A. Babic, Ana Bamlet, William R. Beane-Freeman, Laura Berndt, Sonja I. Blackford, Amanda Borges, Michael Borgida, Ayelet Bracci, Paige M. Brais, Lauren Brennan, Paul Brenner, Hermann Bueno-de-Mesquita, Bas Buring, Julie Campa, Daniele Capurso, Gabriele Cavestro, Giulia Martina Chaffee, Kari G. Chung, Charles C. Cleary, Sean Cotterchio, Michelle Dijk, Frederike Duell, Eric J. Foretova, Lenka Fuchs, Charles Funel, Niccola Gallinger, Steven M. Gaziano, J. Michael Gazouli, Maria Giles, Graham G. Giovannucci, Edward Goggins, Michael Goodman, Gary E. Goodman, Phyllis J. Hackert, Thilo Haiman, Christopher Hartge, Patricia Hasan, Manal Hegyi, Peter Helzlsouer, Kathy J. Herman, Joseph Holcatova, Ivana Holly, Elizabeth A. Hoover, Robert Hung, Rayjean J. Jacobs, Eric J. Jamroziak, Krzysztof Janout, Vladimir Kaaks, Rudolf Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Kooperberg, Charles Kulke, Matthew H. Kupcinskas, Juozas Kurtz, Robert J. Laheru, Daniel Landi, Stefano Lawlor, Rita T. Lee, I.-Min LeMarchand, Loic Lu, Lingeng Malats, Núria Mambrini, Andrea Mannisto, Satu Milne, Roger L. Mohelníková-Duchoňová, Beatrice Neale, Rachel E. Neoptolemos, John P. Oberg, Ann L. Olson, Sara H. Orlow, Irene Pasquali, Claudio Patel, Alpa V. Peters, Ulrike Pezzilli, Raffaele Porta, Miquel Real, Francisco X. Rothman, Nathaniel Scelo, Ghislaine Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Silverman, Debra Smith, Jill P. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Tavano, Francesca Thornquist, Mark D. Tobias, Geoffrey S. Van Den Eeden, Stephen K. Vashist, Yogesh Visvanathan, Kala Vodicka, Pavel Wactawski-Wende, Jean Wang, Zhaoming Wentzensen, Nicolas White, Emily Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Zheng, Wei Kraft, Peter Li, Donghui Chanock, Stephen Obazee, Ofure Petersen, Gloria M. Amundadottir, Laufey T. Nat Commun Article In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10(−8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10(−14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10(−10)), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10(−8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10(−8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. Nature Publishing Group UK 2018-02-08 /pmc/articles/PMC5805680/ /pubmed/29422604 http://dx.doi.org/10.1038/s41467-018-02942-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Klein, Alison P. Wolpin, Brian M. Risch, Harvey A. Stolzenberg-Solomon, Rachael Z. Mocci, Evelina Zhang, Mingfeng Canzian, Federico Childs, Erica J. Hoskins, Jason W. Jermusyk, Ashley Zhong, Jun Chen, Fei Albanes, Demetrius Andreotti, Gabriella Arslan, Alan A. Babic, Ana Bamlet, William R. Beane-Freeman, Laura Berndt, Sonja I. Blackford, Amanda Borges, Michael Borgida, Ayelet Bracci, Paige M. Brais, Lauren Brennan, Paul Brenner, Hermann Bueno-de-Mesquita, Bas Buring, Julie Campa, Daniele Capurso, Gabriele Cavestro, Giulia Martina Chaffee, Kari G. Chung, Charles C. Cleary, Sean Cotterchio, Michelle Dijk, Frederike Duell, Eric J. Foretova, Lenka Fuchs, Charles Funel, Niccola Gallinger, Steven M. Gaziano, J. Michael Gazouli, Maria Giles, Graham G. Giovannucci, Edward Goggins, Michael Goodman, Gary E. Goodman, Phyllis J. Hackert, Thilo Haiman, Christopher Hartge, Patricia Hasan, Manal Hegyi, Peter Helzlsouer, Kathy J. Herman, Joseph Holcatova, Ivana Holly, Elizabeth A. Hoover, Robert Hung, Rayjean J. Jacobs, Eric J. Jamroziak, Krzysztof Janout, Vladimir Kaaks, Rudolf Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Kooperberg, Charles Kulke, Matthew H. Kupcinskas, Juozas Kurtz, Robert J. Laheru, Daniel Landi, Stefano Lawlor, Rita T. Lee, I.-Min LeMarchand, Loic Lu, Lingeng Malats, Núria Mambrini, Andrea Mannisto, Satu Milne, Roger L. Mohelníková-Duchoňová, Beatrice Neale, Rachel E. Neoptolemos, John P. Oberg, Ann L. Olson, Sara H. Orlow, Irene Pasquali, Claudio Patel, Alpa V. Peters, Ulrike Pezzilli, Raffaele Porta, Miquel Real, Francisco X. Rothman, Nathaniel Scelo, Ghislaine Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Silverman, Debra Smith, Jill P. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Tavano, Francesca Thornquist, Mark D. Tobias, Geoffrey S. Van Den Eeden, Stephen K. Vashist, Yogesh Visvanathan, Kala Vodicka, Pavel Wactawski-Wende, Jean Wang, Zhaoming Wentzensen, Nicolas White, Emily Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Zheng, Wei Kraft, Peter Li, Donghui Chanock, Stephen Obazee, Ofure Petersen, Gloria M. Amundadottir, Laufey T. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title_full | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title_fullStr | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title_full_unstemmed | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title_short | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| title_sort | genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680/ https://www.ncbi.nlm.nih.gov/pubmed/29422604 http://dx.doi.org/10.1038/s41467-018-02942-5 |
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