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The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
Circulating CCR2(+) monocytes are crucial for maintaining the adult tissue-resident F4/80(hi)MHCII(hi) macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80(hi)MHCII(low) macrophages, which are the most abundant F4/80(hi) cells in neonates, gra...
Autores principales: | Soncin, Irene, Sheng, Jianpeng, Chen, Qi, Foo, Shihui, Duan, Kaibo, Lum, Josephine, Poidinger, Michael, Zolezzi, Francesca, Karjalainen, Klaus, Ruedl, Christiane |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805689/ https://www.ncbi.nlm.nih.gov/pubmed/29422500 http://dx.doi.org/10.1038/s41467-018-02834-8 |
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