IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation

Epigenetic modifications affect the differentiation of T cell subsets and the pathogenesis of autoimmune diseases, but many mechanisms of epigenetic regulation of T cell differentiation are unclear. Here we show reduced expression of the transcription factor RFX1 in CD4(+) T cells from patients with...

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Detalles Bibliográficos
Autores principales: Zhao, Ming, Tan, Yixin, Peng, Qiao, Huang, Cancan, Guo, Yu, Liang, Gongping, Zhu, Bochen, Huang, Yi, Liu, Aiyun, Wang, Zijun, Li, Mengying, Gao, Xiaofei, Wu, Ruifang, Wu, Haijing, Long, Hai, Lu, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805701/
https://www.ncbi.nlm.nih.gov/pubmed/29422534
http://dx.doi.org/10.1038/s41467-018-02890-0

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