SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is an antioxidant enzyme usually repressed in the tumor milieu. Here we show that specific SOD3 re-expression in tumor-associated en...

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Detalles Bibliográficos
Autores principales: Mira, Emilia, Carmona-Rodríguez, Lorena, Pérez-Villamil, Beatriz, Casas, Josefina, Fernández-Aceñero, María Jesús, Martínez-Rey, Diego, Martín-González, Paula, Heras-Murillo, Ignacio, Paz-Cabezas, Mateo, Tardáguila, Manuel, Oury, Tim D., Martín-Puig, Silvia, Lacalle, Rosa Ana, Fabriás, Gemma, Díaz-Rubio, Eduardo, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805714/
https://www.ncbi.nlm.nih.gov/pubmed/29422508
http://dx.doi.org/10.1038/s41467-018-03079-1

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