Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1

Organic Anion-Transporting Polypeptides are multispecific membrane proteins that regulate the passage of crucial endobiotics and drugs across pharmacological barriers. OATP1B1 and OATP1B3 have been described to play a major role in the hepatic uptake of statins, antivirals and various chemotherapeut...

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Detalles Bibliográficos
Autores principales: Patik, Izabel, Székely, Virág, Német, Orsolya, Szepesi, Áron, Kucsma, Nóra, Várady, György, Szakács, Gergely, Bakos, Éva, Özvegy-Laczka, Csilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805760/
https://www.ncbi.nlm.nih.gov/pubmed/29422623
http://dx.doi.org/10.1038/s41598-018-20815-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805760/
https://www.ncbi.nlm.nih.gov/pubmed/29422623
http://dx.doi.org/10.1038/s41598-018-20815-1

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