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Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C mot...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805841/ https://www.ncbi.nlm.nih.gov/pubmed/29223680 http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.009 |
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author | Bradburn, Steven McPhee, Jamie Bagley, Liam Carroll, Michael Slevin, Mark Al-Shanti, Nasser Barnouin, Yoann Hogrel, Jean-Yves Pääsuke, Mati Gapeyeva, Helena Maier, Andrea Sipilä, Sarianna Narici, Marco Robinson, Andrew Mann, David Payton, Antony Pendleton, Neil Butler-Browne, Gillian Murgatroyd, Chris |
author_facet | Bradburn, Steven McPhee, Jamie Bagley, Liam Carroll, Michael Slevin, Mark Al-Shanti, Nasser Barnouin, Yoann Hogrel, Jean-Yves Pääsuke, Mati Gapeyeva, Helena Maier, Andrea Sipilä, Sarianna Narici, Marco Robinson, Andrew Mann, David Payton, Antony Pendleton, Neil Butler-Browne, Gillian Murgatroyd, Chris |
author_sort | Bradburn, Steven |
collection | PubMed |
description | Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that altered methylation at one of these CpG sites further associated with working memory performance in 2 independent aging cohorts. Studying prefrontal cortex samples, we found higher CXCL10 protein levels in those with Alzheimer's disease, compared with aged controls. These findings support the association of peripheral inflammation, as demonstrated by CXCL10, in aging and cognitive decline. We reveal age-related epigenetic and genetic factors which contribute to the dysregulation of CXCL10. |
format | Online Article Text |
id | pubmed-5805841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-58058412018-03-01 Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance Bradburn, Steven McPhee, Jamie Bagley, Liam Carroll, Michael Slevin, Mark Al-Shanti, Nasser Barnouin, Yoann Hogrel, Jean-Yves Pääsuke, Mati Gapeyeva, Helena Maier, Andrea Sipilä, Sarianna Narici, Marco Robinson, Andrew Mann, David Payton, Antony Pendleton, Neil Butler-Browne, Gillian Murgatroyd, Chris Neurobiol Aging Article Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that altered methylation at one of these CpG sites further associated with working memory performance in 2 independent aging cohorts. Studying prefrontal cortex samples, we found higher CXCL10 protein levels in those with Alzheimer's disease, compared with aged controls. These findings support the association of peripheral inflammation, as demonstrated by CXCL10, in aging and cognitive decline. We reveal age-related epigenetic and genetic factors which contribute to the dysregulation of CXCL10. Elsevier 2018-03 /pmc/articles/PMC5805841/ /pubmed/29223680 http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bradburn, Steven McPhee, Jamie Bagley, Liam Carroll, Michael Slevin, Mark Al-Shanti, Nasser Barnouin, Yoann Hogrel, Jean-Yves Pääsuke, Mati Gapeyeva, Helena Maier, Andrea Sipilä, Sarianna Narici, Marco Robinson, Andrew Mann, David Payton, Antony Pendleton, Neil Butler-Browne, Gillian Murgatroyd, Chris Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title | Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title_full | Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title_fullStr | Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title_full_unstemmed | Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title_short | Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance |
title_sort | dysregulation of c-x-c motif ligand 10 during aging and association with cognitive performance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805841/ https://www.ncbi.nlm.nih.gov/pubmed/29223680 http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.009 |
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