Cargando…

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

BACKGROUND: Type 1 diabetes is typically considered a disease of children and young adults. Genetic susceptibility to young-onset type 1 diabetes is well defined and does not predispose to type 2 diabetes. It is not known how frequently genetic susceptibility to type 1 diabetes leads to a diagnosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Nicholas J, Jones, Samuel E, Weedon, Michael N, Shields, Beverley M, Oram, Richard A, Hattersley, Andrew T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Lancet, Diabetes & Endocrinology 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805861/ https://www.ncbi.nlm.nih.gov/pubmed/29199115 http://dx.doi.org/10.1016/S2213-8587(17)30362-5

Ejemplares similares

Prevalence of Fabry disease-causing variants in the UK Biobank
por: Gilchrist, Mark, et al.
Publicado: (2023)

The impact of population-level HbA(1c) screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis
por: Young, Katherine G., et al.
Publicado: (2022)

Correction to: The impact of population-level HbA(1c) screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis
por: Young, Katherine G., et al.
Publicado: (2023)

Identifying Good Responders to Glucose Lowering Therapy in Type 2 Diabetes: Implications for Stratified Medicine
por: Jones, Angus G., et al.
Publicado: (2014)

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
por: Hall, Lynsey S., et al.
Publicado: (2018)

Characterizing the hypertensive cardiovascular phenotype in the UK Biobank
por: Elghazaly, Hussein, et al.
Publicado: (2023)

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population
por: Freathy, Rachel M, et al.
Publicado: (2006)

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank
por: Johnston, Keira J. A., et al.
Publicado: (2021)

IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank
por: Sukcharoen, Kittiya, et al.
Publicado: (2020)

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18–50 years
por: Lynam, Anita, et al.
Publicado: (2019)

Gene–obesogenic environment interactions in the UK Biobank study
por: Tyrrell, Jessica, et al.
Publicado: (2017)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
por: Freathy, Rachel M, et al.
Publicado: (2006)

Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes
por: Thomas, Nicholas J., et al.
Publicado: (2019)

ANTsX neuroimaging-derived structural phenotypes of UK Biobank
por: Tustison, Nicholas J., et al.
Publicado: (2023)

Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank
por: Green, Harry D., et al.
Publicado: (2022)

Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis
por: Green, Harry D, et al.
Publicado: (2019)

The UK Biobank resource with deep phenotyping and genomic data
por: Bycroft, Clare, et al.
Publicado: (2018)

Telomere length and brain imaging phenotypes in UK Biobank
por: Topiwala, Anya, et al.
Publicado: (2023)

Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank
por: Williams, Camille M., et al.
Publicado: (2023)

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study
por: Tyrrell, Jessica S, et al.
Publicado: (2013)

Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabetes
por: Rodgers, Lauren R, et al.
Publicado: (2017)

Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank
por: Raisi-Estabragh, Zahra, et al.
Publicado: (2021)

Childhood cancer in the UK: achievements and legacy of six decades of research in Oxford
por: Muirhead, Colin R.
Publicado: (2018)

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
por: Tyrrell, Jessica, et al.
Publicado: (2016)

An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank
por: Yonova-Doing, Ekaterina, et al.
Publicado: (2021)

Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study
por: Ruth, Katherine S., et al.
Publicado: (2016)

Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
por: Raisi-Estabragh, Zahra, et al.
Publicado: (2023)

Reference values for intake of six types of soluble and insoluble fibre in healthy UK inhabitants based on the UK Biobank data
por: Shevlyakov, Artem, et al.
Publicado: (2022)

Genome-wide association studies of brain imaging phenotypes in UK Biobank
por: Elliott, Lloyd T., et al.
Publicado: (2018)

Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank
por: Zhu, Xingxing, et al.
Publicado: (2021)

Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank
por: Mahmood, Adil, et al.
Publicado: (2023)

Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
por: Azevedo, Tiago, et al.
Publicado: (2023)

Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank
por: Gubb, Samuel J A, et al.
Publicado: (2020)

The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a β cell phenotype
por: Hamilton, Alexander J, et al.
Publicado: (2014)

Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank
por: Patel, Riyaz S., et al.
Publicado: (2022)

Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank
por: Harris, Mathew A., et al.
Publicado: (2022)

Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging
por: Wang, Chaoyue, et al.
Publicado: (2022)

Membranous nephropathy in the UK Biobank
por: Hamilton, Patrick, et al.
Publicado: (2023)

Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants
por: Ferguson, Amy Christina, et al.
Publicado: (2022)

Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study
por: Cumberland, Phillippa M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oi5n3kvegjt1tj20g3jui20a5e