The synergistic role of ATP‐dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer

The vinorelbine (VRB) plus cisplatin regimen is widely used to treat non–small cell lung cancer (NSCLC), but its cure rate is poor. Drug resistance is the primary driver of chemotherapeutic failure, and the causes of resistance remain unclear. By focusing on the focal adhesion (FA) pathway, we have...

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Detalles Bibliográficos
Autores principales: Nakanishi, Takao, Menju, Toshi, Nishikawa, Shigeto, Takahashi, Koji, Miyata, Ryo, Shikuma, Kei, Sowa, Terumasa, Imamura, Naoto, Hamaji, Masatsugu, Motoyama, Hideki, Hijiya, Kyoko, Aoyama, Akihiro, Sato, Toshihiko, Chen‐Yoshikawa, Toyofumi F., Sonobe, Makoto, Date, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806107/
https://www.ncbi.nlm.nih.gov/pubmed/29318780
http://dx.doi.org/10.1002/cam4.1282

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