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Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

Alzheimer’s disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reductions in secreted amyloid precursor protein-alpha (sAPPα), an al...

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Detalles Bibliográficos
Autores principales:	Tan, Valerie T. Y., Mockett, Bruce G., Ohline, Shane M., Parfitt, Karen D., Wicky, Hollie E., Peppercorn, Katie, Schoderboeck, Lucia, Yahaya, Mohamad Fairuz bin, Tate, Warren P., Hughes, Stephanie M., Abraham, Wickliffe C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806250/ https://www.ncbi.nlm.nih.gov/pubmed/29426354 http://dx.doi.org/10.1186/s13041-018-0348-9

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