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Practical Pharmacology of Methadone: A Long-acting Opioid

Methadone is a naturally long-acting analgesic with unique pharmacodynamic and pharmacokinetic properties compared to other opioids, available now in India, to treat severe pain. It has the potential to dramatically relieve suffering among patients with serious illness who are living with persistent...

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Detalles Bibliográficos
Autores principales: Sunilkumar, MM, Lockman, Kashelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806300/
https://www.ncbi.nlm.nih.gov/pubmed/29497249
http://dx.doi.org/10.4103/IJPC.IJPC_180_17
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author Sunilkumar, MM
Lockman, Kashelle
author_facet Sunilkumar, MM
Lockman, Kashelle
author_sort Sunilkumar, MM
collection PubMed
description Methadone is a naturally long-acting analgesic with unique pharmacodynamic and pharmacokinetic properties compared to other opioids, available now in India, to treat severe pain. It has the potential to dramatically relieve suffering among patients with serious illness who are living with persistent physical pain. However, clinicians must appreciate its unique pharmacologic properties and its use in clinical practice safely and effectively. The available formulation in India is a racemic mixture of the S- and R-enantiomers, and as such, it will have a propensity for drug-drug and drug-genetic interactions that can increase the risk of Torsades de Point and respiratory depression. Appropriate patient selection, careful dosing and thorough monitoring of methadone will mitigate these risks.
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spelling pubmed-58063002018-03-01 Practical Pharmacology of Methadone: A Long-acting Opioid Sunilkumar, MM Lockman, Kashelle Indian J Palliat Care Special Review Methadone is a naturally long-acting analgesic with unique pharmacodynamic and pharmacokinetic properties compared to other opioids, available now in India, to treat severe pain. It has the potential to dramatically relieve suffering among patients with serious illness who are living with persistent physical pain. However, clinicians must appreciate its unique pharmacologic properties and its use in clinical practice safely and effectively. The available formulation in India is a racemic mixture of the S- and R-enantiomers, and as such, it will have a propensity for drug-drug and drug-genetic interactions that can increase the risk of Torsades de Point and respiratory depression. Appropriate patient selection, careful dosing and thorough monitoring of methadone will mitigate these risks. Medknow Publications & Media Pvt Ltd 2018-01 /pmc/articles/PMC5806300/ /pubmed/29497249 http://dx.doi.org/10.4103/IJPC.IJPC_180_17 Text en Copyright: © 2018 Indian Journal of Palliative Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Special Review
Sunilkumar, MM
Lockman, Kashelle
Practical Pharmacology of Methadone: A Long-acting Opioid
title Practical Pharmacology of Methadone: A Long-acting Opioid
title_full Practical Pharmacology of Methadone: A Long-acting Opioid
title_fullStr Practical Pharmacology of Methadone: A Long-acting Opioid
title_full_unstemmed Practical Pharmacology of Methadone: A Long-acting Opioid
title_short Practical Pharmacology of Methadone: A Long-acting Opioid
title_sort practical pharmacology of methadone: a long-acting opioid
topic Special Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806300/
https://www.ncbi.nlm.nih.gov/pubmed/29497249
http://dx.doi.org/10.4103/IJPC.IJPC_180_17
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