Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the pathogenic disease-associated forms of α-synuclein (αSyn(D)) that are sufficiently sensitive, specific, and practical for analysis of accessib...

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Detalles Bibliográficos
Autores principales: Groveman, Bradley R., Orrù, Christina D., Hughson, Andrew G., Raymond, Lynne D., Zanusso, Gianluigi, Ghetti, Bernardino, Campbell, Katrina J., Safar, Jiri, Galasko, Douglas, Caughey, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806364/
https://www.ncbi.nlm.nih.gov/pubmed/29422107
http://dx.doi.org/10.1186/s40478-018-0508-2

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