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Value of information methods to design a clinical trial in a small population to optimise a health economic utility function
BACKGROUND: Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided test. Approval of the experimental treatment by regulatory agencies is then ba...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806391/ https://www.ncbi.nlm.nih.gov/pubmed/29422021 http://dx.doi.org/10.1186/s12874-018-0475-0 |