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A physiologically based model for denitrogenation kinetics

Under normal conditions we continuously breathe 78% nitrogen (N(2)) such that the body tissues and fluids are saturated with dissolved N(2). For normobaric medical gas administration at high concentrations, the N(2) concentration must be less than that in the ambient atmosphere; therefore, nitrogen...

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Autores principales: Katz, Ira, Murdock, Jacqueline, Palgen, Marc, Farjot, Géraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806446/
https://www.ncbi.nlm.nih.gov/pubmed/29497486
http://dx.doi.org/10.4103/2045-9912.222449
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author Katz, Ira
Murdock, Jacqueline
Palgen, Marc
Farjot, Géraldine
author_facet Katz, Ira
Murdock, Jacqueline
Palgen, Marc
Farjot, Géraldine
author_sort Katz, Ira
collection PubMed
description Under normal conditions we continuously breathe 78% nitrogen (N(2)) such that the body tissues and fluids are saturated with dissolved N(2). For normobaric medical gas administration at high concentrations, the N(2) concentration must be less than that in the ambient atmosphere; therefore, nitrogen will begin to be released by the body tissues. There is a need to estimate the time needed for denitrogenation in the planning of surgical procedures. In this paper we will describe the application of a physiologically based pharmacokinetic model to denitrogenation kinetics. The results are compared to the data resulting from experiments in the literature that measured the end tidal N(2) concentration while breathing 100% oxygen in the form of moderately rapid and slow compartment time constants. It is shown that the model is in general agreement with published experimental data. Correlations for denitrogenation as a function of subject weight are provided.
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spelling pubmed-58064462018-03-01 A physiologically based model for denitrogenation kinetics Katz, Ira Murdock, Jacqueline Palgen, Marc Farjot, Géraldine Med Gas Res Research Article Under normal conditions we continuously breathe 78% nitrogen (N(2)) such that the body tissues and fluids are saturated with dissolved N(2). For normobaric medical gas administration at high concentrations, the N(2) concentration must be less than that in the ambient atmosphere; therefore, nitrogen will begin to be released by the body tissues. There is a need to estimate the time needed for denitrogenation in the planning of surgical procedures. In this paper we will describe the application of a physiologically based pharmacokinetic model to denitrogenation kinetics. The results are compared to the data resulting from experiments in the literature that measured the end tidal N(2) concentration while breathing 100% oxygen in the form of moderately rapid and slow compartment time constants. It is shown that the model is in general agreement with published experimental data. Correlations for denitrogenation as a function of subject weight are provided. Medknow Publications & Media Pvt Ltd 2018-01-22 /pmc/articles/PMC5806446/ /pubmed/29497486 http://dx.doi.org/10.4103/2045-9912.222449 Text en Copyright: © 2017 Medical Gas Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Katz, Ira
Murdock, Jacqueline
Palgen, Marc
Farjot, Géraldine
A physiologically based model for denitrogenation kinetics
title A physiologically based model for denitrogenation kinetics
title_full A physiologically based model for denitrogenation kinetics
title_fullStr A physiologically based model for denitrogenation kinetics
title_full_unstemmed A physiologically based model for denitrogenation kinetics
title_short A physiologically based model for denitrogenation kinetics
title_sort physiologically based model for denitrogenation kinetics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806446/
https://www.ncbi.nlm.nih.gov/pubmed/29497486
http://dx.doi.org/10.4103/2045-9912.222449
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