Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence is an anticancer mechanism that arrests proliferation...

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Detalles Bibliográficos
Autores principales: Chinta, Shankar J., Woods, Georgia, Demaria, Marco, Rane, Anand, Zou, Ying, McQuade, Amanda, Rajagopalan, Subramanian, Limbad, Chandani, Madden, David T., Campisi, Judith, Andersen, Julie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806534/
https://www.ncbi.nlm.nih.gov/pubmed/29386135
http://dx.doi.org/10.1016/j.celrep.2017.12.092

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