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CD4(+) T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1

INTRODUCTION: Narcolepsy type 1 is accompanied by a selective loss of orexin/hypocretin (hcrt) neurons in the lateral hypothalamus caused by yet unknown mechanisms. Epidemiologic and genetic associations strongly suggest an immune-mediated pathogenesis of the disease. METHODS: We compared specific T...

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Detalles Bibliográficos
Autores principales:	Ramberger, Melanie, Högl, Birgit, Stefani, Ambra, Mitterling, Thomas, Reindl, Markus, Lutterotti, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806576/ https://www.ncbi.nlm.nih.gov/pubmed/28364420 http://dx.doi.org/10.1093/sleep/zsw070

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