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Molecular determinants of pH regulation in the cardiac Na(+)–Ca(2+) exchanger
The cardiac Na(+)–Ca(2+) exchanger (NCX) plays a critical role in the heart by extruding Ca(2+) after each contraction and thus regulates cardiac contractility. The activity of NCX is strongly inhibited by cytosolic protons, which suggests that intracellular acidification will have important effects...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806679/ https://www.ncbi.nlm.nih.gov/pubmed/29301861 http://dx.doi.org/10.1085/jgp.201611693 |