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(18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study

AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-s...

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Autores principales: Gillebert, Quentin, Huchet, Virginie, Rousseau, Caroline, Cochet, Alexandre, Olivier, Pierre, Courbon, Frédéric, Gontier, Eric, Nataf, Valérie, Balogova, Sona, Talbot, Jean-Noël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806856/
https://www.ncbi.nlm.nih.gov/pubmed/29425221
http://dx.doi.org/10.1371/journal.pone.0191487
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author Gillebert, Quentin
Huchet, Virginie
Rousseau, Caroline
Cochet, Alexandre
Olivier, Pierre
Courbon, Frédéric
Gontier, Eric
Nataf, Valérie
Balogova, Sona
Talbot, Jean-Noël
author_facet Gillebert, Quentin
Huchet, Virginie
Rousseau, Caroline
Cochet, Alexandre
Olivier, Pierre
Courbon, Frédéric
Gontier, Eric
Nataf, Valérie
Balogova, Sona
Talbot, Jean-Noël
author_sort Gillebert, Quentin
collection PubMed
description AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1(st) and 2(nd) questionnaire related to patient’s planned management before and after FCH-PET/CT. Based on data from a 6-month follow-up after FCH-PET/CT, an independent assessor blinded to results of FCH-PET/CT determined the adequacy of management changes motivated by FCH-PET/CT. RESULTS: FCH-PET/CT localised foci evocative of recurrent PCa in 59% (105/179) of patients. Results of FCH-PET/CT motivated a change in scheduled patient management in 56% (100/179) of patients; which was considered as adequate in 89% (89/100) of patients. FCH-PET/CT also led to the detection of lung cancer in two patients. CONCLUSION: FCH PET/CT is a powerful tool to localise the sites of occult biochemical recurrence of PCa, leading to an adequate management change in half of patients.
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spelling pubmed-58068562018-02-23 (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study Gillebert, Quentin Huchet, Virginie Rousseau, Caroline Cochet, Alexandre Olivier, Pierre Courbon, Frédéric Gontier, Eric Nataf, Valérie Balogova, Sona Talbot, Jean-Noël PLoS One Research Article AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1(st) and 2(nd) questionnaire related to patient’s planned management before and after FCH-PET/CT. Based on data from a 6-month follow-up after FCH-PET/CT, an independent assessor blinded to results of FCH-PET/CT determined the adequacy of management changes motivated by FCH-PET/CT. RESULTS: FCH-PET/CT localised foci evocative of recurrent PCa in 59% (105/179) of patients. Results of FCH-PET/CT motivated a change in scheduled patient management in 56% (100/179) of patients; which was considered as adequate in 89% (89/100) of patients. FCH-PET/CT also led to the detection of lung cancer in two patients. CONCLUSION: FCH PET/CT is a powerful tool to localise the sites of occult biochemical recurrence of PCa, leading to an adequate management change in half of patients. Public Library of Science 2018-02-09 /pmc/articles/PMC5806856/ /pubmed/29425221 http://dx.doi.org/10.1371/journal.pone.0191487 Text en © 2018 Gillebert et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gillebert, Quentin
Huchet, Virginie
Rousseau, Caroline
Cochet, Alexandre
Olivier, Pierre
Courbon, Frédéric
Gontier, Eric
Nataf, Valérie
Balogova, Sona
Talbot, Jean-Noël
(18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title_full (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title_fullStr (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title_full_unstemmed (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title_short (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
title_sort (18)f-fluorocholine pet/ct in patients with occult biochemical recurrence of prostate cancer: detection rate, impact on management and adequacy of impact. a prospective multicentre study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806856/
https://www.ncbi.nlm.nih.gov/pubmed/29425221
http://dx.doi.org/10.1371/journal.pone.0191487
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