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(18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study
AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806856/ https://www.ncbi.nlm.nih.gov/pubmed/29425221 http://dx.doi.org/10.1371/journal.pone.0191487 |
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author | Gillebert, Quentin Huchet, Virginie Rousseau, Caroline Cochet, Alexandre Olivier, Pierre Courbon, Frédéric Gontier, Eric Nataf, Valérie Balogova, Sona Talbot, Jean-Noël |
author_facet | Gillebert, Quentin Huchet, Virginie Rousseau, Caroline Cochet, Alexandre Olivier, Pierre Courbon, Frédéric Gontier, Eric Nataf, Valérie Balogova, Sona Talbot, Jean-Noël |
author_sort | Gillebert, Quentin |
collection | PubMed |
description | AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1(st) and 2(nd) questionnaire related to patient’s planned management before and after FCH-PET/CT. Based on data from a 6-month follow-up after FCH-PET/CT, an independent assessor blinded to results of FCH-PET/CT determined the adequacy of management changes motivated by FCH-PET/CT. RESULTS: FCH-PET/CT localised foci evocative of recurrent PCa in 59% (105/179) of patients. Results of FCH-PET/CT motivated a change in scheduled patient management in 56% (100/179) of patients; which was considered as adequate in 89% (89/100) of patients. FCH-PET/CT also led to the detection of lung cancer in two patients. CONCLUSION: FCH PET/CT is a powerful tool to localise the sites of occult biochemical recurrence of PCa, leading to an adequate management change in half of patients. |
format | Online Article Text |
id | pubmed-5806856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58068562018-02-23 (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study Gillebert, Quentin Huchet, Virginie Rousseau, Caroline Cochet, Alexandre Olivier, Pierre Courbon, Frédéric Gontier, Eric Nataf, Valérie Balogova, Sona Talbot, Jean-Noël PLoS One Research Article AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1(st) and 2(nd) questionnaire related to patient’s planned management before and after FCH-PET/CT. Based on data from a 6-month follow-up after FCH-PET/CT, an independent assessor blinded to results of FCH-PET/CT determined the adequacy of management changes motivated by FCH-PET/CT. RESULTS: FCH-PET/CT localised foci evocative of recurrent PCa in 59% (105/179) of patients. Results of FCH-PET/CT motivated a change in scheduled patient management in 56% (100/179) of patients; which was considered as adequate in 89% (89/100) of patients. FCH-PET/CT also led to the detection of lung cancer in two patients. CONCLUSION: FCH PET/CT is a powerful tool to localise the sites of occult biochemical recurrence of PCa, leading to an adequate management change in half of patients. Public Library of Science 2018-02-09 /pmc/articles/PMC5806856/ /pubmed/29425221 http://dx.doi.org/10.1371/journal.pone.0191487 Text en © 2018 Gillebert et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gillebert, Quentin Huchet, Virginie Rousseau, Caroline Cochet, Alexandre Olivier, Pierre Courbon, Frédéric Gontier, Eric Nataf, Valérie Balogova, Sona Talbot, Jean-Noël (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title | (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title_full | (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title_fullStr | (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title_full_unstemmed | (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title_short | (18)F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study |
title_sort | (18)f-fluorocholine pet/ct in patients with occult biochemical recurrence of prostate cancer: detection rate, impact on management and adequacy of impact. a prospective multicentre study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806856/ https://www.ncbi.nlm.nih.gov/pubmed/29425221 http://dx.doi.org/10.1371/journal.pone.0191487 |
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