Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma

Medication-related osteonecrosis of the jaw is a known side-effect of antiresorptive therapy in patients with malignant diseases. Nevertheless, the exact pathogenesis is still unknown and published prevalences show a significant range. The aim of the presented paper was to assess the prevalence of o...

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Autores principales: Rugani, Petra, Walter, Christian, Kirnbauer, Barbara, Acham, Stephan, Begus-Nahrman, Yvonne, Jakse, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806952/
https://www.ncbi.nlm.nih.gov/pubmed/29563474
http://dx.doi.org/10.3390/dj4040032
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author Rugani, Petra
Walter, Christian
Kirnbauer, Barbara
Acham, Stephan
Begus-Nahrman, Yvonne
Jakse, Norbert
author_facet Rugani, Petra
Walter, Christian
Kirnbauer, Barbara
Acham, Stephan
Begus-Nahrman, Yvonne
Jakse, Norbert
author_sort Rugani, Petra
collection PubMed
description Medication-related osteonecrosis of the jaw is a known side-effect of antiresorptive therapy in patients with malignant diseases. Nevertheless, the exact pathogenesis is still unknown and published prevalences show a significant range. The aim of the presented paper was to assess the prevalence of osteonecrosis (ONJ) in breast cancer, prostate cancer, and multiple myeloma patients receiving parenteral antiresorptive therapy. For this reason a PubMed search was performed and 69 matching articles comprising 29,437 patients were included in the analysis. Nine-hundred fifty-one cases of jaw necrosis were described. The overall ONJ-prevalence was 2.09% in the breast cancer group, 3.8% in the prostate cancer group, and 5.16% for multiple myeloma patients.
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spelling pubmed-58069522018-03-16 Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma Rugani, Petra Walter, Christian Kirnbauer, Barbara Acham, Stephan Begus-Nahrman, Yvonne Jakse, Norbert Dent J (Basel) Review Medication-related osteonecrosis of the jaw is a known side-effect of antiresorptive therapy in patients with malignant diseases. Nevertheless, the exact pathogenesis is still unknown and published prevalences show a significant range. The aim of the presented paper was to assess the prevalence of osteonecrosis (ONJ) in breast cancer, prostate cancer, and multiple myeloma patients receiving parenteral antiresorptive therapy. For this reason a PubMed search was performed and 69 matching articles comprising 29,437 patients were included in the analysis. Nine-hundred fifty-one cases of jaw necrosis were described. The overall ONJ-prevalence was 2.09% in the breast cancer group, 3.8% in the prostate cancer group, and 5.16% for multiple myeloma patients. MDPI 2016-09-27 /pmc/articles/PMC5806952/ /pubmed/29563474 http://dx.doi.org/10.3390/dj4040032 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rugani, Petra
Walter, Christian
Kirnbauer, Barbara
Acham, Stephan
Begus-Nahrman, Yvonne
Jakse, Norbert
Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title_full Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title_fullStr Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title_full_unstemmed Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title_short Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma
title_sort prevalence of medication-related osteonecrosis of the jaw in patients with breast cancer, prostate cancer, and multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806952/
https://www.ncbi.nlm.nih.gov/pubmed/29563474
http://dx.doi.org/10.3390/dj4040032
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