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A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research

Mechanistic studies on demineralization-remineralization play a critical role in investigating caries pathogenicity, testing effects of new caries prevention methods, and developing new caries-preventing products. Simulating the cariogenic challenges in the mouth, various demineralization-reminerali...

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Autores principales: Yu, Ollie Yiru, Zhao, Irene Shuping, Mei, May Lei, Lo, Edward Chin-Man, Chu, Chun-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806972/
https://www.ncbi.nlm.nih.gov/pubmed/29563426
http://dx.doi.org/10.3390/dj5020020
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author Yu, Ollie Yiru
Zhao, Irene Shuping
Mei, May Lei
Lo, Edward Chin-Man
Chu, Chun-Hung
author_facet Yu, Ollie Yiru
Zhao, Irene Shuping
Mei, May Lei
Lo, Edward Chin-Man
Chu, Chun-Hung
author_sort Yu, Ollie Yiru
collection PubMed
description Mechanistic studies on demineralization-remineralization play a critical role in investigating caries pathogenicity, testing effects of new caries prevention methods, and developing new caries-preventing products. Simulating the cariogenic challenges in the mouth, various demineralization-remineralization models have been used for cariology research. This review aimed to provide an overview of the common mechanistic studies on demineralization-remineralization for cariology research in recent literature. Most mechanistic studies were in vitro studies (n = 294, 84%) among the 350 cariology studies indexed in the Web of Science from 2014 to 2016. Among these in vitro studies, most studies (257/294, 87%) used chemical models that could be classified as simple mineralization models (159/257, 62%) or pH-cycling models (98/257, 38%). In vitro studies consumed less expense and time than in vivo studies. Furthermore, in vitro conditions were easier to control. However, they could hardly imitate the complex structures of oral cavities, the microbiological effect of oral biofilm, and the hydrodynamic instability of saliva. The advantages of chemical models included simplicity of the study, low cost, efficiency (time saving), reproducibility, and stability of experiments. However, the “caries” generated were not biological. Moreover, the chemical models were generally basic and could not mimic a carious lesion in the complex oral environment.
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spelling pubmed-58069722018-03-16 A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research Yu, Ollie Yiru Zhao, Irene Shuping Mei, May Lei Lo, Edward Chin-Man Chu, Chun-Hung Dent J (Basel) Review Mechanistic studies on demineralization-remineralization play a critical role in investigating caries pathogenicity, testing effects of new caries prevention methods, and developing new caries-preventing products. Simulating the cariogenic challenges in the mouth, various demineralization-remineralization models have been used for cariology research. This review aimed to provide an overview of the common mechanistic studies on demineralization-remineralization for cariology research in recent literature. Most mechanistic studies were in vitro studies (n = 294, 84%) among the 350 cariology studies indexed in the Web of Science from 2014 to 2016. Among these in vitro studies, most studies (257/294, 87%) used chemical models that could be classified as simple mineralization models (159/257, 62%) or pH-cycling models (98/257, 38%). In vitro studies consumed less expense and time than in vivo studies. Furthermore, in vitro conditions were easier to control. However, they could hardly imitate the complex structures of oral cavities, the microbiological effect of oral biofilm, and the hydrodynamic instability of saliva. The advantages of chemical models included simplicity of the study, low cost, efficiency (time saving), reproducibility, and stability of experiments. However, the “caries” generated were not biological. Moreover, the chemical models were generally basic and could not mimic a carious lesion in the complex oral environment. MDPI 2017-06-18 /pmc/articles/PMC5806972/ /pubmed/29563426 http://dx.doi.org/10.3390/dj5020020 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Ollie Yiru
Zhao, Irene Shuping
Mei, May Lei
Lo, Edward Chin-Man
Chu, Chun-Hung
A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title_full A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title_fullStr A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title_full_unstemmed A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title_short A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
title_sort review of the common models used in mechanistic studies on demineralization-remineralization for cariology research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806972/
https://www.ncbi.nlm.nih.gov/pubmed/29563426
http://dx.doi.org/10.3390/dj5020020
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