Cargando…
FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice
Protein quality control in cardiomyocytes is crucial to maintain cellular homeostasis. The accumulation of damaged organelles, such as mitochondria and misfolded proteins in the heart is associated with heart failure. During the process to identify novel mitochondria-specific autophagy (mitophagy) r...
Autores principales: | Misaka, Tomofumi, Murakawa, Tomokazu, Nishida, Kazuhiko, Omori, Yosuke, Taneike, Manabu, Omiya, Shigemiki, Molenaar, Chris, Uno, Yoshihiro, Yamaguchi, Osamu, Takeda, Junji, Shah, Ajay M., Otsu, Kinya |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807029/ https://www.ncbi.nlm.nih.gov/pubmed/29129702 http://dx.doi.org/10.1016/j.yjmcc.2017.11.004 |
Ejemplares similares
-
A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy
por: Murakawa, Tomokazu, et al.
Publicado: (2019) -
Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice
por: Kitazume-Taneike, Rika, et al.
Publicado: (2019) -
Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts
por: Omiya, Shigemiki, et al.
Publicado: (2020) -
mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy
por: Taneike, Manabu, et al.
Publicado: (2016) -
Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
por: Ito, Jumpei, et al.
Publicado: (2021)