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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces. Since in vivo validation is not possible for the h...

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Detalles Bibliográficos
Autores principales:	Morgani, Sophie M, Metzger, Jakob J, Nichols, Jennifer, Siggia, Eric D, Hadjantonakis, Anna-Katerina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Stem Cells and Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807051/ https://www.ncbi.nlm.nih.gov/pubmed/29412136 http://dx.doi.org/10.7554/eLife.32839

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