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THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1
THEMIS, a T cell specific protein that is highly expressed in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive (CABIT) module of unknown function. Here, we show that THEMI...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807080/ https://www.ncbi.nlm.nih.gov/pubmed/28250424 http://dx.doi.org/10.1038/ni.3692 |