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Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4

Ageing and obesity are two major risk factors for the development of type 2 diabetes (T2D). A chronic, low-grade, sterile inflammation contributes to insulin resistance and β-cell failure. Toll-like receptor-4 (TLR4) is a major pro-inflammatory pathway; its ligands as well as downstream signals are...

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Detalles Bibliográficos
Autores principales:	He, Wei, Yuan, Ting, Choezom, Dolma, Hunkler, Hannah, Annamalai, Karthika, Lupse, Blaz, Maedler, Kathrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807311/ https://www.ncbi.nlm.nih.gov/pubmed/29426925 http://dx.doi.org/10.1038/s41598-018-20909-w

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